Results 131 to 140 of about 55,538 (273)

Stoichiometry of AMPA receptors measured by single molecule imaging

, 2018
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are ionotropic glutamate receptors that conduct fast excitatory transmission at the post-synaptic membrane of neurons. AMPA receptors are tetramers composed of four types of subunits,
Yu, Chenlu
core   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

Electrophysiological characterization of the ionotropic glutamate receptors in the mouse retinal amacrine cells

, 2005
The mammalian retina contains around 30 morphological varieties of amacrine cell types. These interneurons receive excitatory glutamatergic input from bipolar cells and provide GABA- and glycinergic inhibition to other cells in the retina. Amacrine cells
Dumitrescu, Olivia Nicola
core  

Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors

, 2008
Plasticity in the brain is essential for maintaining memory and learning and is associated with the dynamic membrane trafficking of AMPA receptors. EphrinB proteins, ligands for EphB receptor tyrosine kinases, are transmembrane molecules with signaling ...
Traut, M., Acker-Palmer, A., Geiger, J. C., Stein, V., Valentin Stein, Klein, R., Essmann, C. L., Traut, M. H., Essmann, C., Zimmer, M., Geiger, J., Rüdiger Klein, Elsa Martinez, Julia C Geiger, Matthias H Traut, Clara L Essmann, Martinez, E., Manuel Zimmer, Amparo Acker-Palmer   +18 more
core   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

AMPA Receptors as Therapeutic Targets for Neurological Disorders

, 2016
Almost every neurological disease directly or indirectly affects synapse function in the brain. However, these diseases alter synapses through different mechanisms, ultimately resulting in altered synaptic transmission and/or plasticity. Glutamate is the
Kevin Lee, Lee, Kevin, Schenk, S, Susan Schenk, Goodman, Lucy, Beulah Leitch, Fourie, Chantelle, Lucy Goodman, Johanna M. Montgomery, Montgomery, Johanna, Chantelle Fourie, Leitch, B   +11 more
core   +1 more source

A functional study of AMPA and kainate receptors

, 2011
The ionotropic glutamate receptors are localized in the pre- and postsynaptic membrane of neurons and mediate the majority of fast excitatory synaptic transmission.
Han, Yan
core   +1 more source

Neurodevelopmental Consequences Induced by Early‐Life Lead Exposure Through Disruption of Neurotransmitter Pathways and Molecular Mechanisms: A Systematic Review

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Lead is a toxic heavy metal with significant health risks, as maternal lead exposure during pregnancy disrupts fetal neural development through placental transfer, leading to persistent neurological, developmental, and long‐term health consequences in the progeny.
P. Harshitha, Aluru Parithathvi, Kamalesh Dattaram Mumbrekar, Herman Sunil Dsouza   +3 more
wiley   +1 more source