Results 141 to 150 of about 86,953 (229)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, Volume 600, Issue 1, Page 83-98, January 2026.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

TVB C++: A Fast and Flexible Back‐End for The Virtual Brain

Advanced Science, Volume 13, Issue 2, 9 January 2026.
TVB C++ is a streamlined and fast C++ Back‐End for The Virtual Brain (TVB), designed to make it as flexible as TVB, and FAST. Another pillar is to be fully compatible with TVB so easy bindings can be created from Python. Users can easily configure TVB C++ to execute the same code but with enhanced performance and parallelism.
Ignacio Martín, Gorka Zamora‐López, Jan Fousek, Michael Schirner, Petra Ritter, Viktor Jirsa, Gustavo Deco, Gustavo Patow   +7 more
wiley   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, Volume 13, Issue 4, 19 January 2026.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

Advanced Science, Volume 13, Issue 2, 9 January 2026.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou, Yukiko Iwasaki, Willy Lutz, Glaucia Almeida, Emilie Béchard, François Delalande, Magali Rompais, Jules Bouget, Barbara Gorda, Chantal Cazevieille, Yonis Bare, Christine Carapito, Sophie Colomb, Gowrishankar Ganesh, Raphael Gaudin   +14 more
wiley   +1 more source

Glutamate-Dependent Dynamic DNA Methylation Regulates Excitatory Amino Acid Transporters in Bergmann Glia Cells: Role of AMPA Receptors. [PDF]

ASN Neuro
Oyetayo BO, Subair T, Morales-Ramírez N, Hernández-Kelly LC, Rodríguez-Campuzano AG, Ramírez-Martínez L, Nolasco-Hiniesta L, Calderón ES, Castelán F, López-Bayghen E, Felder-Schmittbuhl MP, Ortega A.   +11 more
europepmc   +1 more source

Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double‐Blind, and Placebo‐Controlled Trial

Brain and Behavior, Volume 16, Issue 1, January 2026.
In a randomized, double‐blind, placebo‐controlled trial, 50 moderately to severely stressed adults received Restake or placebo for 12 weeks. Psychological outcomes, including anxiety, depression, fatigue, perceived stress, and sleep quality, were evaluated alongside stress‐related biomarkers.
Ahmad Safiyyu'd‐din Hisamuddin, Faiqah Ramli, Teik Kee Leo, Mohamad Shazeli Che Zain, Mei Szin Wong, Mohd Raili Suhaili, Le Jie Lee, Tze Yan Lee   +7 more
wiley   +1 more source

Differing ionotropic glutamate receptor gene expression in paraventricular hypothalamic nucleus subregions following angiotensin II hypertension in male mice and female mice with advanced ovarian failure. [PDF]

Neuroendocrinology
Sommer G, Omar Hussein S, Milner TA, Glass MJ.   +3 more
europepmc   +1 more source

Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers

Human Brain Mapping, Volume 47, Issue 1, January 2026.
A computational laminar model links fast interneuron dysfunction to early hyperexcitability and late hypoactivity in Alzheimer's disease, reproducing key M/EEG biomarkers and capturing the disease's biphasic electrophysiological progression. ABSTRACT Early‐stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity.
Roser Sanchez‐Todo, Borja Mercadal, Edmundo Lopez‐Sola, Maria Guasch‐Morgades, Gustavo Deco, Giulio Ruffini   +5 more
wiley   +1 more source

Therapeutic Potential of Leptin in Neurodegenerative Disease. [PDF]

Biomedicines
Harvey J.
europepmc   +1 more source