Results 141 to 150 of about 42,075 (217)

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

eLife
Chemical synapses are the major sites of communication between neurons in the nervous system and mediate either excitatory or inhibitory signaling.
Aya Matsui, Cathy Spangler, Johannes Elferich, Momoko Shiozaki, Nikki Jean, Xiaowei Zhao, Maozhen Qin, Haining Zhong, Zhiheng Yu, Eric Gouaux   +9 more
doaj   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Spontaneous Ca2+ signals in the developing mammalian cochlea of live mice under different anaesthetic regimes

Experimental Physiology, EarlyView.
Abstract The pre‐hearing mouse cochlea undergoes critical periods of spontaneous Ca2+‐dependent activity that spreads across non‐sensory supporting cells and inner hair cells (IHCs). These signals have been shown to regulate not only the refinement of neural circuits along the auditory pathway towards functional maturity, but also the maturation of the
Francesca De Faveri, Walter Marcotti, Federico Ceriani   +2 more
wiley   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Associations of Dietary Decanoic Acid Intake With Cognitive Function in the Elderly and the Mediating Effects of Hypertension and Diabetes: An Analysis From NHANES 2011–2014

Brain and Behavior, Volume 16, Issue 2, February 2026.
This study included elderly people aged 60 and above in the NHANES 2011–2014 cycle. The research indicated that increased dietary decanoic acid intake was associated with better cognitive function in the elderly, among which diabetes and hypertension were statistically associated with a partial mediating effect, although causality cannot be inferred ...
Huangxin Zhu, Qingan Fu, Juanjuan Hu, Yihong Wu, Jun Min   +4 more
wiley   +1 more source

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum

Glia, Volume 74, Issue 2, February 2026.
Stronger expression of Ca2+ permeable AMPA receptors in cerebellar versus hippocampal NG2 glia. Different expression patterns of glial AMPA receptors and auxiliary subunits in both regions. Higher efficacy of neuron‐NG2 glia synapses in the cerebellum.
Dario Tascio, Nehal Gebril, Ronald Jabs, Christian Henneberger, Christian Steinhäuser, Gerald Seifert   +5 more
wiley   +1 more source

Associations Between Growth Differentiating Factor‐15 and Frailty in Older Adults From the MAPT Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF‐15), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age‐related conditions.
Juan Luis Sánchez‐Sánchez, Yves Rolland, Alexandre Lucas, Sophie Guyonnet, Bruno Vellas, Philipe de Souto Barreto, for the MAPT/DSA Group   +6 more
wiley   +1 more source