Results 141 to 150 of about 2,321,962 (333)

A Thermodynamic Model for Receptor Clustering [PDF]

, 1999
Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv   +1 more source

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

Science, 2019
Forgetting and receptor removal The trafficking of AMPA receptors to and from the surface of postsynaptic membranes regulates synaptic strength and underlies learning and memory. Awasthi et al.
Ankit Awasthi, Binu Ramachandran, Saheeb Ahmed, E. Benito, Y. Shinoda, Noam Nitzan, A. Heukamp, Sabine Rannio, H. Martens, Jonas Barth, K. Burk, Y. T. Wang, A. Fischer, Camin Dean   +13 more
semanticscholar   +1 more source

How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models [PDF]

, 2011
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters.
Aihara, Akbarian, Andreasen, Angulo, Beasley, Bernd Porr, Bi, Bower, Christoph Kolodziejski, Clopath, De Schutter, De Schutter, Egerton, Feinberg, Florentin Wörgötter, Freund, Guidotti, Hebb, Iglesias, Jolivet, Kehrer, Klopf, Koch, Lewis, Lindskog, Lisman, Lynsey McCabe, Magee, Markram, Morris, O’Mann, Paolo di Prodi, Paz, Pierri, Porr, Porr, Ragland, Rapoport, Rubin, Saudargiene, Shinoda, Somogyi, Straub, Tamosiunaite, Tamosiunaite, Tamosiunaite, Traub, Ulrich, Voegtlin, Yang, Zaitsev   +50 more
core   +1 more source

Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease [PDF]

, 2009
The exact nature of the comorbidity between cardiovascular disease (CVD) and major depressive disorder (MDD) is poorly understood. The proposed mechanisms include various biochemical and molecular pathways as well as health behaviors such as physical ...
Chen, Hu
core   +3 more sources

Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder

Journal of Neuroscience, 2012
Activity-dependent modifications of excitatory synapses contribute to synaptic maturation and plasticity, and are critical for learning and memory. Consequently, impairments in synapse formation or synaptic transmission are thought to be responsible for ...
Kenneth R. Myers, Guangfu Wang, Yanghui Sheng, Kathryn K. Conger, J. Casanova, J. J. Zhu   +5 more
semanticscholar   +1 more source

Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition

Epilepsia Open, EarlyView.
Abstract The Ankyrin 2 (ANK2) gene encodes the ankyrin‐B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long QT syndrome and autism.
Po‐Hsi Lin, Chen‐Jui Ho, Chih‐Hsiang Lin, Ya‐Yuan Hou, Cheng‐Han Chan, Meng‐Han Tsai   +5 more
wiley   +1 more source

Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades

Kidney Research and Clinical Practice, 2014
Background: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and α isoform of calcium/calmodulin-dependent protein kinase II (αCaMKII) is fundamentally ...
Jong Wan Kim, Gyoung Yim Ha, Yong Wook Jung   +2 more
doaj   +1 more source

A neuroeconomic theory of bidirectional synaptic plasticity and addiction [PDF]

arXiv, 2011
Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent ...
arxiv  

Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]

, 1992
The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source