Results 181 to 190 of about 2,321,962 (333)
Establishment and characterization of adap1‐deficient zebrafish
Development, Growth &Differentiation, EarlyView.To examine the physiological functions of the adap1 gene, we have established zebrafish adap1 mutants lacking functional PH1 and PH2 domains. The adap1 mutants showed no apparent morphological abnormalities and grew to adulthood. We found that the adult adap1 mutants spent more time than the wild type in the regions near the chambers where novel ...
Atsuo Kawahara +7 more
wiley +1 more source
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]
, 1995 To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel +2 more
core +1 more source
Developmental Medicine &Child Neurology, EarlyView.Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan +5 more
wiley +1 more source
AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures
Neurobiology of Disease, 1999 Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez +1 more
doaj
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Nature, 2021 Jie Yu +5 more
semanticscholar +1 more source
Epilepsia, EarlyView.Abstract Objective The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand the mechanisms that explain the differences in sleep homeostasis observed in children with epilepsy. Methods We used a neural mass model to replicate sleep electroencephalography (EEG) recorded from 15 children with focal ...
Dominic M. Dunstan +2 more
wiley +1 more source
Effects of Electroacupuncture on Syt3 and GluA2 in Rats With Limb Spasms After Intracerebral Hemorrhage. [PDF]
Brain BehavThe limb spasm after ICH is associated with the expression of Syt3 and GluA2 and the formation of CP‐AMPARs in the upper motor neurons. Electroacupuncture improves spasticity post‐ICH through downregulating the expression of Syt3 and inhibiting the interaction of Syt3 and GluA2.
Lu X +9 more
europepmc +2 more sources
Epilepsia, EarlyView.Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder +4 more
wiley +1 more source
Neurotransmitter receptors: AMPA receptors: now you see them, now you don't
Nature Reviews Neuroscience, 2001 J. López
semanticscholar +1 more source