Results 31 to 40 of about 2,321,962 (333)
Uncorking AMPA receptors [PDF]
Journal of General Physiology, 2017 New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs.
openaire +2 more sources
Actin/alpha-actinin-dependent transport of AMPA receptors in dendritic spines: role of the PDZ-LIM protein RIL [PDF]
, 2004 The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the synaptic sites.
Dittgen, T. +11 more
core +1 more source
Resensitizing AMPA receptors [PDF]
Journal of General Physiology, 2019 JGP study suggests how the regulatory protein γ8 reopens AMPA receptor channels in the continued presence of glutamate.
openaire +2 more sources
p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
Nature Communications, 2019 AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge +10 more
doaj +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Science, 2019 Diversity in ion channel complexes AMPA receptors are glutamate activated ion channels that mediate fast synaptic transmission in the nervous system and play a key role in learning and memory.
Yan Zhao +4 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2023 Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission and are implicated in various neurological disorders. In this review, we discuss the role of the two fastest iGluRs subtypes, namely, α-amino-3-hydroxy-5-methyl ...
Marina N. Vukolova +5 more
doaj +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation [PDF]
, 1998 Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output.
Ehlers, Michael D +5 more
core +1 more source
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
Brain : a journal of neurology, 2018 Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), which interacts with voltage-gated ...
Mar Petit-Pedrol +12 more
semanticscholar +1 more source