Results 41 to 50 of about 45,095 (165)

AMPA Receptor Activation [PDF]

Neuron, 2004
AMPA receptors are tetramers assembled as a dimer-of-dimers with a 2-fold rotational symmetry in their extracellular domains. Two papers in this issue of Neuron, by Horning and Mayer and Sobolevsky et al., provide complementary data that extend this view and highlight the role of dimers in channel gating.
openaire   +3 more sources

Development of AMPA Receptor Aptamers [PDF]

Biophysical Journal, 2010
The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate ion channel receptors plays an essential role in the mammalian brain activities such as memory and learning, whereas the excessive receptor activation has been implicated in neurological diseases such as stroke, epilepsy, and amyotrophic lateral sclerosis.
Zhen Huang, Weimin Pei, Sabarinath Jayaseelan, Li Niu, Yan Han, Jae Seon Park   +5 more
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Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2021
Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb, Ali Harb, Nils Vogel, Ali Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann, Ralf Mohrmann   +7 more
doaj   +1 more source

Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model

Neuroscience Research
NMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors.
Qingchen Guo
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Clathrin-Independent Trafficking of AMPA Receptors [PDF]

The Journal of Neuroscience, 2015
Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPAR turnover and internalization of AMPARs during slow homeostatic forms of synaptic plasticity remain ...
Glebov, Oleg O, Tigaret, Cezar M, Mellor, Jack R, Henley, Jeremy M   +3 more
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SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons

Neuroscience Research
Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
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Mechanisms of AMPA Receptor Endosomal Sorting [PDF]

Frontiers in Molecular Neuroscience, 2018
The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T., Hanley, Jonathan G.   +1 more
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Allosteric competition and inhibition in AMPA receptors

Nature Structural & Molecular Biology, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey   +6 more
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Modulating Excitatory Synaptic Neurotransmission: Potential Treatment for Neurological Disease?

Neurobiology of Disease, 1998
Excitatory neurotransmission at many CNS synapses depends upon AMPA-type glutamate receptors. Derangements in AMPA receptor-mediated synaptic transmission may be a contributing factor in neurological and neurodegenerative diseases and could be a target ...
Kelvin A. Yamada
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
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