Results 71 to 80 of about 2,321,962 (333)

Clathrin-Independent Trafficking of AMPA Receptors [PDF]

The Journal of Neuroscience, 2015
Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPAR turnover and internalization of AMPARs during slow homeostatic forms of synaptic plasticity remain ...
Glebov, Oleg, Tigaret, Cezar M., Mellor, Jack R., Henley, Jeremy M.   +3 more
openaire   +4 more sources

Assembly of AMPA receptors: mechanisms and regulation

Journal of Physiology, 2014
AMPA receptors (AMPARs) play a critical role in excitatory glutamatergic neurotransmission. The number and subunit composition of AMPARs at synapses determines the dynamics of fast glutamatergic signalling.
Quan Gan, Catherine L. Salussolia, L. Wollmuth   +2 more
semanticscholar   +1 more source

Mechanisms of AMPA Receptor Endosomal Sorting [PDF]

Frontiers in Molecular Neuroscience, 2018
The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T., Hanley, Jonathan G.   +1 more
openaire   +6 more sources

Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells [PDF]

, 2017
There is increasing evidence that diabetic retinopathy is a primary neuropathological disorder that precedes the microvascular pathology associated with later stages of the disease.
Ambrósio, António F., Castilho, Aurea, Hartveit, Espen, Madsen, Eirik, Veruki, Margaret Lin   +4 more
core   +1 more source

Superactivation of AMPA receptors by auxiliary proteins [PDF]

Nature Communications, 2016
AbstractGlutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins ...
Andrew J.R. Plested, Andrew J.R. Plested, Anna L. Carbone   +2 more
openaire   +4 more sources

Degradation of Glyphosate to Benign N‐Formyl Glycine Using MOF‐808 Nanocrystals

Angewandte Chemie, EarlyView.
A Zr‐based metal–organic framework (MOF‐808) with different crystal sizes and designed defect sites was employed as an efficient heterogeneous catalyst for the complete degradation of glyphosate at room temperature. The degradation mechanism produces N‐formyl glycine and hydroxymethyl‐phosphonate. Abstract Glyphosate (N‐phosphonomethyl glycine, GPh) is
Jhair A. Peña Prada, Tatiana A. Huertas Navarro, Stephange L. Chua, Alejandro M. Granados, Chih‐Wen Pao, Alejandro M. Fracaroli, Nicholas M. Bedford   +6 more
wiley   +2 more sources

Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]

, 2015
Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina, DI ANGELANTONIO, SILVIA, LIMATOLA, Cristina, PAGANI, FRANCESCA, PICCININ, Sonia, RAGOZZINO, Davide Antonio, ROSITO, MARIA, TRETTEL, Flavia   +7 more
core   +1 more source

Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor [PDF]

, 2023
As a subclass of ionotropic glutamate receptors (iGluRs), α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors have been implicated in various neurological disorders and neurodegenerative diseases.
Chen, Jiahui, Chen, Zhen, Collier, Lee, Dong, Chenchen, Elghazawy, Nehal H., Haider, Ahmed, He, Wenpeng, Huang, Yiman, Li, Guocong, Li, Ying, Li, Yinlong, Liang, Steven H., Liao, Kai, Ran, Wenqing, Rong, Jian, Sippl, Wolfgang, Wang, Lu, Wei, Huiyi, Wei, Junjie, Xu, Hao   +19 more
core   +1 more source

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit

European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022
Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Antonio Malgaroli   +3 more
wiley   +1 more source

Synaptic transmission and plasticity in the spinal cord substantia gelatinosa: the role of GluR2, GluR5 and GluR6 glutamate receptor subunits [PDF]

, 2002
To understand the physiological role of the AMPA-type or kainate-type ionotropic glutamate receptors and their participation in sensory information processing, including pain, it will be necessary to develop a comprehensive description of their actions ...
Youn, Dong-ho
core   +3 more sources