Results 1 to 10 of about 50 (50)
Autoantigen-B Cell Antigen Receptor Interactions That Regulate Expression of B Cell Antigen Receptor Loci [PDF]
The Journal of Immunology, 2007 AbstractLevels of AgR (BCR) expression are regulated during B cell development, activation, and induction of tolerance. The mechanisms responsible for and consequences of this regulation are poorly understood. We have described a class of DNA-based autoantigen-reactive B cell that down-regulates BCR expression during development to mature follicular ...
Lawrence J. Wysocki +2 more
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Role of Specific B-Cell Receptor Antigens in Lymphomagenesis [PDF]
Frontiers in Oncology, 2020 The B-cell receptor (BCR) signaling pathway is a crucial pathway of B cells, both for their survival and for antigen-mediated activation, proliferation and differentiation. Its activation is also critical for the genesis of many lymphoma types. BCR-mediated lymphoma proliferation may be caused by activating BCR-pathway mutations and/or by active or ...
Lorenz Thurner +8 more
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Antigen footprint governs activation of the B cell receptor
Nature Communications, 2023 AbstractAntigen binding by B cell receptors (BCR) on cognate B cells elicits a response that eventually leads to production of antibodies. However, it is unclear what the distribution of BCRs is on the naïve B cell and how antigen binding triggers the first step in BCR signaling.
Alexey Ferapontov +12 more
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Memory control by the B cell antigen receptor
Immunological Reviews, 2018 SummaryThe generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ‐globulin ...
Niklas Engels, Jürgen Wienands
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Activation of the Rap1 GTPase by the B Cell Antigen Receptor [PDF]
Journal of Biological Chemistry, 1998 The B cell antigen receptor (BCR) activates Ras, a GTPase that promotes cell proliferation by activating the Raf-1/MEK/ERK signaling module and other signaling enzymes. In its active GTP-bound form, the Rap1 GTPase may act as a negative regulator of Ras-mediated signaling by sequestering Ras effectors (e.g., Raf-1) and preventing their activation.
Robert J. Ingham +4 more
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Resting and activated states of the B cell antigen receptor [PDF]
Cell Communication and Signaling, 2009 Each B cell contains up to 100,000 B cell antigen receptor (BCR) complexes on its surface, which only become fully active on exposure of the B cell to its cognate antigen. Most studies on BCR function aims at a better understanding how the BCR becomes active and transmits its signal to the many signaling pathways inside the cell.
Yogesh Kulathu +4 more
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The B cell antigen receptor in B-cell development
Current Opinion in Immunology, 1994 During B-cell development, immature and mature forms of the B cell antigen receptor complex are deployed in a regulated fashion; thus, B cell antigen receptor complexes play essential roles in the transit of cells through ontogeny. The past year has seen progress in our understanding of how antigen receptor gene assembly is controlled and in defining ...
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B‐cell antigen‐receptor signalling in lymphocyte development [PDF]
Immunology, 2003 SummarySignalling through the B‐cell antigen receptor (BCR) is required throughout B‐cell development and peripheral maturation. Targeted disruption of BCR components or downstream effectors indicates that specific signalling mechanisms are preferentially required for central B‐cell development, peripheral maturation and repertoire selection ...
Marcus R. Clark, Leo D. Wang
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The Memory Function of the B Cell Antigen Receptor
, 2015 Abstract Activated B lymphocytes preserve their antigen experience by differentiating into long-lived pools of antibody-secreting plasma cells or various types of memory B cells (MBCs). The former population constantly produces serum immunoglobulins with sufficient specificity and affinity to thwart infections with recurrent pathogens.
Jürgen Wienands, Niklas Engels
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Chimeric Antigen Receptor Therapy for B-cell Malignancies [PDF]
Journal of Cancer, 2011 We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce rapid and potent anti-tumor activity in chemotherapy refractory CLL patients.
David L. Porter +4 more
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