Results 21 to 30 of about 673,183 (288)
The case for absolute ligand discrimination : modeling information processing and decision by immune T cells [PDF]
, 2015 Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of absolute discrimination is recognition of not-self by immune T Cells. We show
Altan-Bonnet, Grégoire, François, Paul
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Memory control by the B cell antigen receptor
Immunological Reviews, 2018 SummaryThe generation of memory B cells (MBCs) that have undergone immunoglobulin class switching from IgM, which dominates primary antibody responses, to other immunoglobulin isoforms is a hallmark of immune memory. Hence, humoral immunological memory is characterized by the presence of serum immunoglobulins of IgG subtypes known as the γ‐globulin ...
Niklas Engels, Jürgen Wienands
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Activation of the Rap1 GTPase by the B Cell Antigen Receptor [PDF]
Journal of Biological Chemistry, 1998 The B cell antigen receptor (BCR) activates Ras, a GTPase that promotes cell proliferation by activating the Raf-1/MEK/ERK signaling module and other signaling enzymes. In its active GTP-bound form, the Rap1 GTPase may act as a negative regulator of Ras-mediated signaling by sequestering Ras effectors (e.g., Raf-1) and preventing their activation.
Robert J. Ingham +4 more
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F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
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STAR Protocols, 2021 Summary: This protocol describes how to identify Dual Expressers (DEs), a rare type of lymphocyte that co-expresses B-cell receptors and T-cell receptors, by flow cytometry using a cocktail of four antibodies. It also shows the subsequent gating strategy
Rizwan Ahmed +5 more
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F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
Resting and activated states of the B cell antigen receptor [PDF]
Cell Communication and Signaling, 2009 Each B cell contains up to 100,000 B cell antigen receptor (BCR) complexes on its surface, which only become fully active on exposure of the B cell to its cognate antigen. Most studies on BCR function aims at a better understanding how the BCR becomes active and transmits its signal to the many signaling pathways inside the cell.
Yogesh Kulathu +4 more
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Haematologica, 2014 Chronic lymphocytic leukemia B cells express auto/xeno antigen-reactive antibodies that bind to self-epitopes and resemble natural IgM antibodies in their repertoire.
Ann-Charlotte Bergh +6 more
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Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. [PDF]
, 2006 Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection.
A. Meyer +108 more
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Nanobody based dual specific CARs [PDF]
, 2018 Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich +8 more
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