Results 21 to 30 of about 50 (50)
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Association of CD22 with the B cell antigen receptor
European Journal of Immunology, 1993AbstractThe antigen receptor on B lymphocytes is composed of membrane immunoglobulin sheathed by an α/β heterodimer. This structure is in several respects analogous to the antigen receptor on T cells except that, in the case of the T cell but not the B cell receptor, several receptor‐associated proteins have been described which may modulate the ...
Michael S. Neuberger +1 more
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B cell antigen receptor signaling 101
Molecular Immunology, 2004All cells continually survey their environment and make decisions based on cues encountered. This requires specific receptors that detect such cues, then transduce signals that initiate the appropriate responses. B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-receptor (BCR ...
Aimee E. Pugh-Bernard +5 more
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Current Opinion in Immunology, 1994
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen ...
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Compartmentalization of B-cell antigen receptor functions
Molecular Immunology, 1996Receptor tyrosine kinases (RTK), like the PDGF-receptor, translate information from the extracellular environment into cytoplasmic signals that regulate a spectrum of cellular functions. RTK molecules consist of ligand binding extracellular domains, cytoplasmic kinase domains and tyrosine phosphorylation sites [Ullrich and Schlessinger, 1990 (Cell 61 ...
A. C. Lankester, R. A. W. Van Lier
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Signal Transduction by the B‐Cell Antigen Receptor
Annals of the New York Academy of Sciences, 1995The antigen receptor of B lymphocytes (BCR) plays important roles in recognition of foreign antigens and self-components to allow the immune system to make appropriate antibody responses. The BCR is a complex between membrane immunoglobulin and the Ig-alpha and Ig-beta heterodimer.
Debbie Law +10 more
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Stability of the B cell antigen receptor complex
Molecular Immunology, 2000The B cell antigen receptor (BCR) comprises the membrane-bound immunoglobulin (mIg) molecule and the Ig-alpha/Ig-beta heterodimer. By comparing the stability of the IgD-BCR and IgM-BCR in different detergent lysates, we find that the IgD-BCR is more stable than the IgM-BCR.
Wolfgang W. A. Schamel, Michael Reth
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Structure and Function of the B Cell Antigen Receptor
Annual Review of Cell Biology, 1993INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 STRUCTURE OF THE B CELL ANTIGEN RECEPTOR . . . . . . . . . . . . . . . . . 378 SIGNAL TRANSDUCTION FUNCTION OF THE ANTIGEN RECEPTOR . . . . . 382 TARGETS OF ANTIGEN RECEPTOR-STIMULATED TYROSINE PHOSPHORYLATION . . . . . . . . . . . . . . . . . . . . . .
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Journal of Allergy and Clinical Immunology, 1999
Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A. Oshiba, Erwin W. Gelfand
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Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell antigen receptors also can direct B-cell differentiation, although the mechanisms are not well defined and the effects on
A. Oshiba, Erwin W. Gelfand
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2010
1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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1 Structure and Synthesis of the BCR 2 BCR Signaling 3 BCR Antigen Uptake Function 4 Functions of the BCR in B-Cell Maturation and Activation 5 Conclusion Keywords: B-cell antigen receptor (BCR); BCR signaling; B lymphocytes and making antibodies; pre-BCR and B-cell development; protein tyrosine kinase activation by BCR;
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Transmembrane signalling by the B-cell antigen receptor
Current Opinion in Immunology, 1994Crosslinking the B-cell antigen receptor is sufficient to generate intracellular signals. Recent work has shown that this signalling capability can be ascribed to the presence of the alpha and beta sheath proteins within the antigen receptor that couple it to signal transduction pathways.
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