Results 41 to 50 of about 1,004,480 (189)

Targeting human langerin promotes HIV-1 specific humoral immune responses.

PLoS Pathogens, 2021
The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z Igyártó, Yves Levy, Sylvain Cardinaud   +22 more
doaj   +1 more source

Can We Improve Vaccine Efficacy by Targeting T and B Cell Repertoire Convergence?

Frontiers in Immunology, 2019
Traditional vaccine development builds on the assumption that healthy individuals have virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B cell receptor (BCR) and TCR respectively].
Katja Fink
doaj   +1 more source

Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors. [PDF]

, 2019
In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta ...
Baybutt, Trevor R., Caparosa, Ellen M., Flickinger, John C., Snook, Adam E.   +3 more
core   +1 more source

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

Nature Communications, 2016
Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate ...
Pascal Blanc, Ludovic Moro-Sibilot, Lucas Barthly, Ferdinand Jagot, Sébastien This, Simon de Bernard, Laurent Buffat, Sébastien Dussurgey, Renaud Colisson, Elias Hobeika, Thierry Fest, Morgan Taillardet, Olivier Thaunat, Antoine Sicard, Paul Mondière, Laurent Genestier, Stephen L. Nutt, Thierry Defrance   +17 more
doaj   +1 more source

B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting

Cell Reports, 2018
Summary: Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation for follicular helper T cells.
Jackson Steed Turner, Fang Ke, Irina Leonidovna Grigorova   +2 more
doaj   +1 more source

B-cell Development and Primary Antibody Deficiencies [PDF]

, 2007
B lymphocytes are generated throughout life from hematopoietic stem cells in bone marrow, and contribute to the immune system by the production of antigen-specific antibodies (immunoglobulins; Ig).
Zelm, M.C. (Menno) van
core   +1 more source

Transition between immune and disease states in a cellular automaton model of clonal immune response

, 1997
In this paper we extend the Celada-Seiden (CS) model of the humoral immune response to include infectious virus and cytotoxic T lymphocytes (cellular response).
Abbas, Boon, Britton, Celada, Celada, Celada, Danielak, Farmer, Fishman, Franco Celada, Grossman, Guckenheimer, Hiernaux, Hiernaux, Karunaweera, Kaufman, Lawrence, Lippert, Lo, Michele Bezzi, Morel, Morpurgo, Philip E. Seiden, Romagnani, Romball, Stefano Ruffo, Wolfram   +26 more
core   +2 more sources

The B cell antigen receptor in B-cell development

Current Opinion in Immunology, 1994
During B-cell development, immature and mature forms of the B cell antigen receptor complex are deployed in a regulated fashion; thus, B cell antigen receptor complexes play essential roles in the transit of cells through ontogeny. The past year has seen progress in our understanding of how antigen receptor gene assembly is controlled and in defining ...
openaire   +2 more sources

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus [PDF]

Nature, 2013
Influenza A virus-specific B lymphocytes and the antibodies they produce protect against infection. However, the outcome of interactions between an influenza haemagglutinin-specific B cell via its receptor (BCR) and virus is unclear. Through somatic cell nuclear transfer we generated mice that harbour B cells with a BCR specific for the haemagglutinin ...
Dougan, Stephanie K., Ashour, Joseph, Karssemeijer, Roos A., Popp, Maximilian W., Avalos, Ana M., Barisa, Marta, Altenburg, Arwen F., Ingram, Jessica R., Cragnolini, Juan J., Guo, Chunguang, Alt, Frederick W., Jaenisch, Rudolf, Ploegh, Hidde   +12 more
openaire   +4 more sources

EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms

Frontiers in Immunology
During lymphocyte development, a diverse repertoire of lymphocyte antigen receptors is produced to battle against pathogens, which is the basis of adaptive immunity.
Li Li, Daiquan Zhang, Xinmei Cao
doaj   +1 more source