Results 61 to 70 of about 1,004,480 (189)
eLife, 2019 B lymphocytes use B cell receptors (BCRs) to recognize antigens. It is still not clear how BCR transduces antigen-specific physical signals upon binding across cell membrane for the conversion to chemical signals, triggering downstream signaling cascades.
Zhixun Shen +6 more
doaj +1 more source
An Introduction to Rule-based Modeling of Immune Receptor Signaling
, 2017 Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory response ...
Faeder, James R., Sekar, John A. P.
core +1 more source
Cellular-level versus receptor-level response threshold hierarchies in T-Cell activation [PDF]
, 2013 Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others.
Andrew Kelvin Sewell +12 more
core +3 more sources
Antigen Receptor Signals Rescue B Cells from TLR Tolerance [PDF]
The Journal of Immunology, 2009 Abstract Interactions between innate and adaptive immune receptors are critical for an optimal immune response, but the role played by Ag receptors in modulating innate receptor functions is less clear. TLRs are a family of pattern recognition receptors that play crucial roles in detecting microbial pathogens and subsequent ...
Jayakumar S, Poovassery +2 more
openaire +2 more sources
Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy
Frontiers in Immunology, 2020 Today, vaccinologists have come to understand that the hallmark of any protective immune response is the antigen. However, it is not the whole antigen that dictates the immune response, but rather the various parts comprising the whole that are capable ...
Kyle Saylor +5 more
doaj +1 more source
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources
Self-antigen recognition by follicular lymphoma B-cell receptors [PDF]
Blood, 2012 Abstract Follicular lymphoma is a monoclonal B-cell malignancy with each patient's tumor expressing a unique cell surface immunoglobulin (Ig), or B-cell receptor (BCR), that can potentially recognize antigens and/or transduce signals into the tumor cell.
Kacey L, Sachen +8 more
openaire +2 more sources
Inhibitory B cell co-receptors and autoimmune diseases
Immunological Medicine, 2019 B cells express various inhibitory co-receptors including CD22 (also known as Siglec-2), Siglec-10 (Siglec-G in mice), CD72, LILRB (PIR-B in mice) and FcγRIIB that contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region ...
Takeshi Tsubata
doaj +1 more source
Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies
Frontiers in Oncology, 2019 Taking advantage of the immune system to exert an antitumor effect is currently a novel approach in cancer therapy. Adoptive transfer of T cells engineered to express chimeric antigen receptors (CARs) targeting a desired antigen has shown extraordinary ...
Jiali Cheng +7 more
doaj +1 more source
The Symmetrical Immune Network Theory and a New HIV Vaccine Concept [PDF]
, 2010 The symmetrical immune network theory is based on Jerne’s network hypothesis. An improved version of the theory is presented. The theory is characterized by symmetrical stimulatory, inhibitory and killing interactions between idiotypic and ...
Geoffrey W. Hoffmann
core +1 more source