Results 91 to 100 of about 27,293 (229)

Actuation of Cell Layers in Three Dimensions

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
ABSTRACT The alignment of fibers and cells in living tissues affect their mechanical properties and functionality. In this context, one can draw an analogy between tissues and nematic liquid crystal elastomers. We explore this analogy by growing fibroblasts on 2D‐patterned substrates and observing the contraction of cell sheets upon detachment from the
Kirsten Endresen, Aniruddh Murali, Birte C. Geerds, Grecia M. Valenzuela Portillo, Maria Bloksgaard, Daniel J.G. Pearce, Francesca Serra   +6 more
wiley   +1 more source

Bovine natural killer cell subsets can be defined by differential expression of CD161 (<i>KLRB1</i>). [PDF]

Front Immunol
Dry I, Kalandadze M, Wu Z, McGuinnes IC, Edmans MD, Benedictus L, Connelley T, Hope JC, Waddell LA.   +8 more
europepmc   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Harnessing the potential of γδ T cells through engineering and combination treatment for cancer therapies. [PDF]

Nat Commun
Fisher J, Wu Y, Abate-Daga D, Barisa M, Lamb L.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Translational potential of γδ T cells in hematologic diseases: from immunobiology to therapeutic innovation. [PDF]

Front Immunol
Zhou X, Zhai M, Zhang Z, Zhang G.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

CXCR3 signaling promotes Delta One T cell recruitment and antitumor efficacy in colorectal cancer. [PDF]

J Immunother Cancer
Carreira M, Barros L, Cruz RM, Ferreira C, Costa C, Ferreira CM, Mensurado S, Silva-Santos B, Blanco-Domínguez R.   +8 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Immune imbalance in rheumatoid arthritis: insights from γδ T cell receptor phenotyping. [PDF]

Hum Cell
Biały S, Wielińska J, Tyczyńska KM, Świerkot J, Bogunia-Kubik K.   +4 more
europepmc   +1 more source