Results 221 to 230 of about 701,449 (267)
Some of the next articles are maybe not open access.
Multimolecular associations of the T-cell antigen receptor
Trends in Cell Biology, 1992T cells are activated when the T-cell receptor for antigen (TCR) interacts with an antigenic peptide bound to a major histocompatibility complex (MHC) molecule on the surface of another cell. It is often assumed that T-cell activation is induced by the crosslinking of TCRs.
A D, Beyers, L L, Spruyt, A F, Williams
openaire +2 more sources
T cell antigen receptor signal transduction
Current Opinion in Cell Biology, 1997The T cell antigen receptor (TCR) initiates signal transduction by activating multiple cytoplasmic protein tyrosine kinases (PTKs). Considerable progress in the field of TCR signal transduction has been made in three areas recently: first, in understanding the structure and function of the PTK ZAP-70; second, in the elucidation of the function of the ...
D, Qian, A, Weiss
openaire +2 more sources
T cell antigen-receptor signal transduction
Current Opinion in Immunology, 1999During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways.
J E, van Leeuwen, L E, Samelson
openaire +2 more sources
Function of the Antigen Receptor in T Cell Activation
1988The studies described here, including ours and those of others, were aimed at understanding the mechanism(s) by which the T cell antigen receptor transmits signals that result in expression of lymphokine genes. They have focused both on the proximal molecules and biochemical events that account for transmembrane signalling, as well as on the more ...
M A, Goldsmith, A, Weiss
openaire +2 more sources
Molecular Genetics of T-Cell Antigen Receptors
Hospital Practice, 1988The immunoglobulin paradigm has led to characterization of genetic controls of the T-cell antigen receptor and has correctly predicted mechanisms for generating diversity. With the isolation of the T-cell antigen-receptor molecule and the genes that encode it, a major step has been taken toward understanding and treating a wide range of immune-related ...
openaire +2 more sources
Internalization (but no recycling) of T cell receptor, T3 antigen, and other T cell antigens.
Transplantation proceedings, 1987Item does not contain ...
Tax, W.J.M. +3 more
openaire +2 more sources
The T-cell receptor for antigen.
Immunology. Supplement, 1988There are two important questions concerning the T-cell antigen receptor. Firstly, what is the structural basis of major histocompatibility complex (MHC)-restricted recognition? Secondly, what is the origin of tolerance to self-MHC and the 'learning' of MHC-restricted recognition during thymus development?
openaire +1 more source