Results 201 to 210 of about 701,449 (267)

Immune regulatory mechanisms in the tumor microenvironment and their applications in cancer therapy: from basic research to clinical translation. [PDF]

Front Immunol
Feng Y, Wang Y, Li X, Wang Y, Zhang M.
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

CAR-engineering of innate and innate-like immune cells: a new horizon in adoptive cell therapy for solid tumors. [PDF]

J Immunother Cancer
Nardo G, Putti F, Indini A, Del Vecchio M, De Braud F, Di Nicola M, De Santis F.   +6 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Advances in natural killer cell immunotherapy for hematologic malignancies. [PDF]

Cancer Biol Ther
Hu H, Xiong Y, Xia M, Sheng L.
europepmc   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

How <i>Mycobacterium tuberculosis</i> Subverts Innate and Adaptive Immunity and Their Crosstalk: Implications for Vaccine Design. [PDF]

Vaccines (Basel)
Prasad GVRK, Philips JA.
europepmc   +1 more source

Cellular immunotherapy in melanoma: the next frontier in cancer treatment. [PDF]

J Exp Clin Cancer Res
Wien AL, Stamtsis-Datsi A.
europepmc   +1 more source

Tumor infiltrating lymphocytes against solid tumors: current trends & perspectives. [PDF]

PeerJ
Liew ZM, Low YS, Oh KC, Lee QY, Tye GJ, Bayliss R, Mai CW, Teo MYM, In LLA.   +8 more
europepmc   +1 more source

The role of the complement system in gastrointestinal-related diseases. [PDF]

Front Immunol
Yong B, Luo Z, Luo B, Liu J, Zeng Z, Zheng X.   +5 more
europepmc   +1 more source