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Innate immune regulation of adaptive immunity: mechanisms, implications, and bias. [PDF]

Front Immunol
Zhang Y, Qin Y, Cheng Z.
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The gamma T-cell antigen receptor

Journal of Clinical Immunology, 1987
The gamma-TCR is encoded by genes composed of V, J, and C elements that demonstrate a limited potential for recombinational diversity. These genes are rearranged, transcribed, and translated into proteins early during thymic ontogeny. Lymphocytes express gamma-TCR proteins on the plasma membrane only in association with the CD3 complex.
L L, Lanier, A T, Serafini, J J, Ruitenberg, S, Cwirla, N A, Federspiel, J H, Phillips, J P, Allison, A, Weiss   +7 more
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THE STRUCTURE OF THE T CELL ANTIGEN RECEPTOR

Annual Review of Immunology, 1996
▪ Abstract  Recent crystallographic studies of T cell antigen receptor (TCR) fragments from the α and β chains have now confirmed the expected structural similarity to corresponding immunoglobulin domains. Although the three-dimensional structure of a complete TCR αβ heterodimer has not yet been determined, these results support the view that the ...
G A, Bentley, R A, Mariuzza
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The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

Annual Review of Immunology, 1986
The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene have been cloned, and their structure, organization, ontogeny of expression, pattern of rearrangement, and diversification are now generally understood. In most cases, the immunoglobulin paradigm applied very well to the corresponding phenomena in T cells, although as
M, Kronenberg, G, Siu, L E, Hood, N, Shastri   +3 more
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Antigen-specific T cell receptors

1987
Publisher Summary This chapter discusses immunoglobulin-related T cell receptors. It also presents the production of antibodies to both antigen-binding T cell receptors that are known to be related to immunoglobulin variable regions and to the α/β heterodimers that do not bind antigen, but are encoded by rearranged genes showing sufficient homology ...
J J, Marchalonis, S F, Schluter
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T cell antigen receptor antibodies

Nature, 1987
Immunology has a long tradition of using the immune system to study the immune system. Monoclonal antibodies are now being focused upon the antigen receptor of the T lymphocyte.
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Specificity of the T Cell Receptor for Antigen

1988
Publisher Summary This chapter discusses the evolutionary and organismal influences of the specificity of the T cell receptor that may have contributed to a particular strategy of immune recognition. Understanding the specificity of recognition in the immune system is uniquely complicated because of the vast diversity of the specific receptors.
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T-cell antigen receptors in rheumatoid arthritis

Immunologic Research, 1994
Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by chronic inflammation mainly in the joints. Several lines of evidence suggest that T cells are involved in the pathogenesis of the disease. RA is associated with certain HLA-DR alleles.
L I, Sakkas, P F, Chen, C D, Platsoucas
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Advances in chimeric antigen receptor T cells

Current Opinion in Hematology, 2020
Purpose of review To discuss the important advances in CAR T cell therapy over the past year, focusing on clinical results where available. Recent findings Approximately 30 years after they were first conceived of and 15 years after the first small-scale single-center clinical ...
Ofrat, Beyar-Katz, Saar, Gill
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