Results 131 to 140 of about 4,036 (179)

A synthetic peptide that is a bombesin receptor antagonist

Nature, 1984
The tetradecapeptide bombesin was originally isolated from frog skin. Bombesin-like peptides have since been detected in mammalian gastrointestinal tract, brain and lung. These peptides have potent pharmacological effects on the central nervous system; they cause contraction of intestinal, uterine and urinary tract smooth muscle; and stimulate the ...
R T, Jensen, S W, Jones, K, Folkers, J D, Gardner   +3 more
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Bombesin-Like Peptides: Of Ligands and Receptors

1993
Publisher Summary The bombesin-like peptides comprise a large family of peptides common to frogs and man. Bombesin when injected into rats proved to have a wide variety of pharmacologic effects, including effects on body temperature, cardiac output, blood pressure, and the release of gastrointestinal hormones.
E R, Spindel, E, Giladi, T P, Segerson, S, Nagalla   +3 more
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[D-Phe12]bombesin analogues: a new class of bombesin receptor antagonists

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987
Previous attempts to develop analogues of bombesin that function as specific receptor antagonists have been unsuccessful. Alteration of the histidine in luteinizing hormone releasing factor has resulted in analogues that function as competitive antagonists. In the present study we have used a similar strategy and altered the histidine in bombesin.
P, Heinz-Erian, D H, Coy, M, Tamura, S W, Jones, J D, Gardner, R T, Jensen   +5 more
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A synthetic glycine-extended bombesin analogue interacts with the GRP/bombesin receptor

European Journal of Pharmacology, 2000
alpha-amidation of a peptide (which takes place from a glycine-extended precursor) is required to produce biologically active amidated hormones, such as gastrin-releasing peptide (GRP)/Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH(2) (bombesin).
C, Oiry, J, Pannequin, N, Bernad, A M, Artis, J C, Galleyrand, C, Devin, M, Cristau, J A, Fehrentz, J, Martinez   +8 more
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Potent bombesin receptor antagonists distinguish receptor subtypes

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1990
To determine whether newly described bombesin (BN) receptor antagonists distinguish subtypes of BN receptors, we investigated their abilities to interact with BN receptors on esophageal muscle or pancreatic acinar tissue. For inhibition of binding of 125I-[Tyr4]BN to rat pancreatic tissue, the relative potencies were [D-Phe6]BN-(6-13)ethyl ester (5 nM)
T, von Schrenck, L H, Wang, D H, Coy, M L, Villanueva, S, Mantey, R T, Jensen   +5 more
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Assays of Bombesin Receptors

1991
Publisher Summary This chapter explores the methods that can be used for radioligand binding studies of bombesin receptors in membranes, cells, and tissue sections. Bombesin was originally isolated from extracts of the skin of European frog Bombina bombina and later shown to have a mammalian counterpart in the neurotransmitter gastrin-releasing ...
Steven R. Vigna, Patrick W. Mantyh
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Desmethionine-bombesin receptor antagonist blocks bombesin-induced inhibition of alcohol intake

Alcohol, 1994
[D-Phe6,Des-Met14]bombesin(6-14), ethyl amide (D-BN) is a specific, competitive receptor antagonist of bombesin, a neuropeptide that inhibits alcohol and food intake. We tested the effects of IP injected D-BN (4-400 micrograms/kg) on bombesin-induced (4 micrograms/kg) reduction of caloric intake. In the first experiment, ad lib-fed female and male rats
B A, Carr, J D, Ballou, D A, Marrinan, P J, Kulkosky   +3 more
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Biology of mammalian bombesin-like peptides and their receptors

Current Opinion in Endocrinology, Diabetes & Obesity, 2011
This review will highlight recent advances in the understanding of mammalian bombesin receptor-related pathophysiological roles in disease states and new insights into bombesin receptor pharmacology.Studies regarding bombesin-like peptides and mammalian bombesin receptor functions have demonstrated significant biological impact on a broad array of ...
Ishita D, Majumdar, Horst C, Weber
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Bombesin-like peptides and their receptors

Current Opinion in Endocrinology & Diabetes and Obesity, 2015
To highlight the research progress of roles of bombesin-like peptides and their receptors in pharmacology and physiology.Several new bombesin-derived radioactive or nonradioactive compounds were designed for the diagnosis and therapy of tumors that are overexpressing bombesin receptors.
Man, Guo, Xiangping, Qu, Xiao-Qun, Qin
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Biology and pharmacology of bombesin receptor subtype-3

Current Opinion in Endocrinology, Diabetes & Obesity, 2012
This review summarizes the results of recent studies regarding the biology and pharmacology of novel synthetic agonists and antagonists of the bombesin receptor subtype-3 (BRS-3).All three mammalian bombesin receptors including gastrin-releasing peptide receptor, the neuromedin B receptor, and the BRS-3 have been shown to regulate energy balance and ...
Ishita D, Majumdar, Horst C, Weber
openaire   +2 more sources