Results 141 to 150 of about 26,165 (305)

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone, Marcello Silvestro, Antonio Munafò, Marina Romozzi, Pierangelo Geppetti, Antonio Russo   +5 more
wiley   +1 more source

Efficacy of a multidisciplinary 5‐day headache day‐clinic program: A prospective quasi‐experimental pre–post study in primary headache disorders

Headache: The Journal of Head and Face Pain, EarlyView.
xxxx Abstract Objective To evaluate the effects of a short, structured multimodal day‐clinic program on health‐related quality of life and disability in patients with primary headache disorders. Background Although monoclonal antibodies targeting the calcitonin gene‐related peptide (CGRP) pathway have substantially advanced migraine prophylaxis, a ...
Nadja Fiebig, Luise Bartsch, Christine Klötzer, Josephine Gewand, Johanna Ruhnau, Sebastian Strauß, Uwe Reuter, Robert Fleischmann   +7 more
wiley   +1 more source

Online interest in calcitonin gene‐related peptide‐therapies: An infodemiology study using Google trends

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To evaluate changes in public interest in calcitonin gene‐related peptide therapies associated with major product lifecycle milestones using online search data from the United States and Europe. Background Calcitonin gene‐related peptide therapies have transformed migraine treatment, but the impact of key product lifecycle milestones
Bradley Ong, Jad El Ahdab, Nicolas Thompson, Maithili Bhagat, John Ney, Allison L. Weathers   +5 more
wiley   +1 more source

Lifestyle triggers of migraine: Sleep restriction and caffeine lower the threshold for migraine-like responses in rats in a sex-specific manner. [PDF]

Headache
Plain Language Summary Sleep restriction increases sensitivity to migraine triggers. In this study, rats exposed to sleep restriction and caffeine showed more intense and longer‐lasting pain responses after receiving migraine‐inducing peptides, with female animals showing the strongest effects.
de Oliveira GC, Baggio DF, Lejeune VBP, Quinelato LS, da Luz FMR, Zampronio AR, Fischer L, Chichorro JG.   +7 more
europepmc   +2 more sources

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats

Neuroscience Research
The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents.
Tyler J. Gustafson, Lauren E. McGrath, Matthew R. Hayes, Elizabeth G. Mietlicki-Baase   +3 more
doaj   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

A Possible Role for Calcitonin-Gene-Related Peptide in the Regulation of the Smooth Muscle Tone of the Bladder and Penis [PDF]

, 1990
Lue, Tom F., Francois Benard, Bosch, Ruud J. L. H., Stief, Christian Georg, Bénard, Francois, Sherif R. Aboseif, Tom F. Lue, Ruud J.L.H. Bosch, Tanagho, Emil A., Emil A. Tanagho, Christian G. Stief, Aboseif, Sherif R.   +11 more
core   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source