Results 121 to 130 of about 26,165 (305)

Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia

The Journal of Headache and Pain
Background The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain.
Tayla A. Rees, Zoe Tasma, Michael L. Garelja, Simon J. O’Carroll, Christopher S. Walker, Debbie L. Hay   +5 more
doaj   +1 more source

Calcitonin gene‐related peptide receptors in human gastrointestinal epithelia

, 1994
Calcitonin gene‐related peptide receptors in human gastrointestinal ...
HM Cox (14474847), IR Tough (14474838)
core  

Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin

, 1993
Two receptors with high affinity for salmon calcitonin were cloned from the nucleus accumbens region of rat brain. The deduced 479 amino acid sequence of cDNA clone L2175-D20 (designated Cla receptor) is 78% and 66% identical with those reported for ...
Beaumont, Kevin, Candace X. Moore, Albrandt, Keith, Brady, Elize M.G., John Herich, Mull, Emily, Herich, John, Moore, Candace X., Emily Mull, Kevin Beaumont, Keith Albrandt, Elize M.G. Brady   +11 more
core   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Sites of interaction between calcitonin-family peptides and their receptors

, 2011
The calcitonin-family of peptides comprises calcitonin, amylin, calcitonin gene-related peptides (CGRPs), adrenomedullin (AM) and AM2. Their receptors are calcitonin receptorlike receptor (CLR) or calcitonin receptor (CTR) and receptor activity-modifying
Qi, Tao
core  

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core  

Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges

, 2011
Adrenomedullin (AM), adrenomedullin 2 (AM2/intermedin) and calcitonin gene-related peptide (CGRP) are members of the calcitonin family of peptides. They can act as growth or survival factors for a number of tumours, including those that are endocrine ...
Hay, Deborah, Poyner, DR, Walker, Christopher   +2 more
core   +1 more source

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors

, 2020
Class B G protein-coupled receptors are highly therapeutically relevant but challenges remain in identifying suitable small-molecule drugs. The calcitonin-like receptor (CLR) in particular is linked to conditions such as migraine, cardiovascular disease,
Lydia P. Liew (3901207), Risha Sudra (8612334), Rebekah L. Bower (5674772), David M. Smith (155808), Garry Pairaudeau (1822774), Muriel Bonnet (743493), Debbie L. Hay (2323294), Muhammad A. Jamaluddin (8612325), Michael P. Hay (2314951), Jason M. Booe (4173412), Keith D. Richards (8612328), Augen A. Pioszak (1898617), Jack U. Flanagan (140667), Roxana-Maria Rujan (8612331), Nicole Prodan (8492235), Christopher S. Walker (4369444), Erica R. Hendrikse (8612322), Christopher A. Reynolds (473093)   +17 more
core   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source