Results 201 to 210 of about 26,165 (305)

Population Pharmacokinetics and Exposure‐Response Analyses for Ubrogepant Efficacy and Safety in the Acute Treatment of Migraine: Analysis of Phase 1–3 Studies

The Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.
Abstract A population pharmacokinetic (popPK) model was developed for ubrogepant using data from 10 Phase 1, 1 Phase 2, and 2 Phase 3 studies. The data were described by a 2‐compartment model with linear elimination and transit compartment absorption. Formulation, food intake, race, gender, and hepatic impairment had a statistically significant impact ...
Sven Stodtmann, Lucia Siovitz, Heiko Babel, Ramesh R. Boinpally   +3 more
wiley   +1 more source

Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond. [PDF]

J Headache Pain
Scuteri D, Kodounis M, Katsuki M, Bezgal B, Bednarczyk N, Alevetsovitis SK, Wołos J, Henriques M, Pinheiro TA, MaassenVanDenBrink A, Lampl C, School of Advanced Studies of the European Headache Federation (EHF-SAS).   +11 more
europepmc   +1 more source

Deciphering nodal burden in thyroid carcinoma: A dedicated survey of age, lymph node ratio, log odds of positive nodes, and preoperative prediction models

Journal of Intelligent Medicine, Volume 3, Issue 2, Page 169-191, June 2026.
Abstract Evidence regarding the prognosis of thyroid carcinoma is heterogeneous, ranging from age effects and nodal burden metrics, such as lymph node ratio (LNR) and log odds of positive nodes (LODDS), to preoperative imaging models comprising ultrasound, CEUS, and radiomics.
Mennatallah Sherif, Mohanad A. Deif, Eman K. Elsayed   +2 more
wiley   +1 more source

Meningeal neuropeptide and neuroimmune interactions in the context of migraine. [PDF]

J Headache Pain
Adi T, Gold MS.
europepmc   +1 more source

Analysis of calcitonin receptor binding and function

Receptors form a basic intermediary as the acceptor site for signals that are transmitted between the cells that make up our body. Modulation of receptors, therefore, forms a key target in our ability to treat disease.

core  

Decoding the Neurological Connection Between Rosacea and Migraines: Exploring Shared Mechanisms. [PDF]

Cureus
Arain A, Babar M, Martins N, Lee D.
europepmc   +1 more source

Nasal Air‐Jet Sensitivity Differentiates Empty Nose Syndrome and Turbinate Reduction Patients: A Pilot Study

The Laryngoscope, Volume 136, Issue 6, Page 2491-2498, June 2026.
This prospective pilot study aims to compare nasal mucosal sensitivity to air‐jet stimuli between ENS patients and patients who underwent septoplasty/turbinate reduction (septo‐turb) surgery, but without ENS symptoms. The ENS group had a significantly higher (less sensitive) threshold than the septo‐turb group for the septum opposing the center of the ...
Kanghyun Kim, Ahmad Odeh, Jack Harness, Nidhi Jha, Veronica Formanek, Joseph Lee, Bradley Otto, Kathleen Kelly, Kai Zhao   +8 more
wiley   +1 more source

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, Volume 2, Issue 2, Page 204-213, June 2026.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation. [PDF]

Biomedicines
Kang T, Qiu Z, Aodeng S, Liu Y, Zhu Z, Lv W.   +5 more
europepmc   +1 more source

Effects of the peptides endothelin and CGRP on cerebral blood vessels in vitro [PDF]

, 2004
Szok Délia
core