Results 191 to 200 of about 27,078 (238)

Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity. [PDF]

Front Med (Lausanne)
Macaubas C, Bayram B, Hussein N, Jager A, Davis KL, Graf J, Nakamura M, Zisman D, Mellins ED.   +8 more
europepmc   +1 more source

HIF1 inhibition targets tumoral and myeloid cells, and is a promising therapy for metastatic castration-resistant prostate cancer. [PDF]

Cell Death Dis
Yanushko D, Pichot A, Vincent A, Keime C, Laverny G, Metzger D.   +5 more
europepmc   +1 more source

Heme-induced activation of the TLR3/TRIF-IFN-I-CCL2 pathway contributes to kidney injury in sickle cell disease.

Blood
Liu Y, Shayo S, Su S, Bao W, Zhong H, Murakhovskaya I, Lobo CA, An X, Manwani D, Shi PA, Yazdanbakhsh K.   +10 more
europepmc   +1 more source

Essential involvement of a chemokine receptor, CCR2, to liver metastasis

Essential involvement of a chemokine receptor, CCR2, to liver metastasis
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Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells

The Journal of Immunology, 1997
Abstract We have derived anti-human CCR2-specific mAbs by immunization with synthetic peptides corresponding to CCR2 sequences presumably involved in the interaction with its ligand(s). The characterization of these mAbs includes the ability to recognize the CCR2 receptor specifically, as well as the function based on their ability to
J M, Frade, M, Mellado, G, del Real, J C, Gutierrez-Ramos, P, Lind, C, Martinez-A   +5 more
openaire   +2 more sources

The CCR2 receptor as a therapeutic target

Expert Opinion on Therapeutic Patents, 2005
The strict control of cell recruitment during the physiological inflammatory response fails in autoimmune inflammatory diseases. The chemokine system is a complex and redundant network of small soluble proteins and G-protein-coupled cell surface receptors that participate in the inflammatory response, mainly attracting cells to the inflammatory foci ...
Manuel Feria, Federico Díaz-González
openaire   +1 more source

PCSK9 regulates the chemokine receptor CCR2 on monocytes

Biochemical and Biophysical Research Communications, 2017
Monocyte migration is a key element in atherosclerosis. LDL-C facilitates monocyte migration via induction of CCR2. PCSK9 regulates cell surface expression of the LDL-R and is expressed in vascular smooth muscle cells (VSMCs). The present study was done to investigate the regulation of PCSK9 in VSMCs and its impact on monocyte function.PCSK9 mRNA and ...
Jana, Grune, Heike, Meyborg, Taisiya, Bezhaeva, Kai, Kappert, Philipp, Hillmeister, Ulrich, Kintscher, Burkert, Pieske, Philipp, Stawowy   +7 more
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Regulation of CCR2 chemokine receptor mRNA stability

Journal of Leukocyte Biology, 1997
Abstract During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA.
L, Xu, R, Rahimpour, L, Ran, C, Kong, A, Biragyn, J, Andrews, M, Devries, J M, Wang, D J, Kelvin   +8 more
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CCR2: A characteristic chemokine receptor in normal and pathological intestine

Cytokine, 2023
C-C motif chemokine receptor 2 (CCR2), together with its ligands, especially C-C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in vivo environment. Scientometric methods are used to analyze intestine-related CCR2 expression.
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