Results 201 to 210 of about 27,078 (238)

CCR2 chemokine receptor and AIDS progression

Nature Medicine, 1997
Recently we reported an association between the CCR2-64I chemokine receptor mutation and delayed onset of AIDS. Michael et al. have now examined the San Francisco Mens Health Study (SFMHS) AIDS cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the CCR2-64I association.
Smith, Michael W., Carrington, Mary, Winkler, Cheryl, Lomb, Deborah A., Dean, Michael, Huttley, Gavin A., O'Brien, Stephen J.   +6 more
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Homology modeling of human CCR2 receptor

Medicinal Chemistry Research, 2010
Homology model of CCR2 receptor was built on the basis of the crystal structure of human beta-2 adrenoceptor (PDB ID-2RH1). The model showed 99.3% residues in the core and allowed regions of the Ramachandran plot and there was no residue present in the disallowed regions.
Rajesh Singh, M. Elizabeth Sobhia
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Implication of CCR2 Chemokine Receptor in Cocaine-Induced Sensitization

Journal of Molecular Neuroscience, 2011
Cocaine-induced sensitization induces long-term neuroplastic changes in the striatum. Among these, extracellular signal-regulated kinase (ERK) is a fundamental component in striatal gene and epigenetic regulation and plays an important role in reward processes. As previous studies suggested that the chemokine CCL2 enhanced striatal dopamine release and
Trocello, Jean Marc, Rostène, William, Melik-Parsadaniantz, Stéphane, Godefroy, David, Roze, Emmanuel, Kitabgi, Patrick, Kuziel, William, Chalon, Sylvie, Caboche, Jocelyne, Apartis, Emmanuelle   +9 more
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Chemokine receptor CCR2 involvement in skeletal muscle regeneration

The FASEB Journal, 2004
ABSTRACT Chemokines, signaling through the CCR2 receptor, are highly expressed in injured skeletal muscle. Their target specificity depends on the cellular expression of the specific receptors. Here we demonstrate that, in freeze‐injured muscle, CCR2 co‐localized with Mac‐3, a marker of activated macrophages as well as with myogenin ...
Gordon L, Warren, Tracy, Hulderman, Dawn, Mishra, Xin, Gao, Lyndell, Millecchia, Laura, O'Farrell, William A, Kuziel, Petia P, Simeonova   +7 more
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Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

Clinical Science, 2017
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16−CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes ...
Carolina N, França, Maria C O, Izar, Marinella N S, Hortêncio, Jônatas B, do Amaral, Carlos E S, Ferreira, Izabela D, Tuleta, Francisco A H, Fonseca   +6 more
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Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2007
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).
Anthony B, Pinkerton, Dehua, Huang, Rowena V, Cube, John H, Hutchinson, Mary, Struthers, Julia M, Ayala, Pasquale P, Vicario, Sima R, Patel, Thomas, Wisniewski, Julie A, DeMartino, Jean-Michel, Vernier   +10 more
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The Influence of Chemokine Receptor CCR2 Genotypes in the Route to Cervical Carcinogenesis

Gynecologic and Obstetric Investigation, 2007
Invasive squamous cell carcinomas of the cervix arise from earlier, reversible precursor lesions called low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively). The aim of our study was to analyse the influence of the <i>CCR2-64I</i> polymorphism in the development of SIL due to its preponderant role in the ...
Ana, Coelho, Ana, Matos, Raquel, Catarino, Daniela, Pinto, Hugo, Sousa, Deolinda, Pereira, Rui, Medeiros   +6 more
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Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

Archives of Pharmacal Research, 2013
Chemokines are members of the chemoattractant cytokine family. They play key roles in the trafficking of leukocytes and in the induction of chemotaxis through the activation of G protein-coupled receptor. Considerable interest has been paid to these molecules to elucidate their roles in the unique inflammatory responses elicited in the central nervous ...
Shambhunath, Bose, Jungsook, Cho
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Chemokine receptor CCR2 undergoes transportin1‐dependent nuclear translocation

PROTEOMICS, 2008
Abstract Chemokines (CCs) are small chemoattractant cytokines involved in a wide variety of biological and pathological processes. Released by cells in the milieu, and extracellular matrix and activating signalling cascades upon binding to specific G protein‐coupled receptors (GPCRs), they trigger many cellular events.
Nicolas, Favre, Montserrat, Camps, Christian, Arod, Christian, Chabert, Christian, Rommel, Christian, Pasquali   +5 more
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Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis

International Journal of Molecular Medicine, 2003
The aim of this study was to examine the association of human autoimmune myasthenia gravis (MG) with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64I. CCR2 and CCR5 interact primarily with the human CC family ligands CCL2 (formerly called monocyte chemoattractant protein; MCP-1), CCL3 and CCL4 (macrophage inflammatory protein-
Xiaoyan, Zhao, Baback, Gharizadeh, Peter, Hjelmström, Ritva, Pirskanen, Pål, Nyrén, Ann-Kari, Lefvert, Mehran, Ghaderi   +6 more
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