Results 211 to 220 of about 27,078 (238)

The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

Journal of Molecular Medicine, 2005
CCR2 has been widely considered as a potential therapeutic target for autoimmune disease, particularly rheumatoid arthritis, and various CCR2 blocking agents have been developed, some of which have entered clinical trials. In this review, we examine the relevant information regarding the role of CCR2, and to a lesser extent of the closely related ...
Marlon P, Quinones, Carlos A, Estrada, Yogeshwar, Kalkonde, Sunil K, Ahuja, William A, Kuziel, Matthias, Mack, Seema S, Ahuja   +6 more
openaire   +2 more sources

Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke

Brain, Behavior, and Immunity, 2018
Stroke is the second cause of mortality worldwide and occurs following the interruption of cerebral blood circulation by cerebral vessel burst or subsequent to a local thrombus formation. Ischemic lesion triggers an important inflammatory response, characterized by massive infiltration of leukocytes, activation of glial cells and neurovascular ...
Giulia, Cisbani, Audrey, Le Behot, Marie-Michèle, Plante, Paul, Préfontaine, Manon, Lecordier, Serge, Rivest   +5 more
openaire   +2 more sources

Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis

European Journal of Neurology, 2004
The chemokine monocyte chemoattractant protein (MCP)‐1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2–CCR2 axis are scarce in MS.
Sørensen, Torben Lykke, Ransohoff, R M, Strieter, R M, Sellebjerg, F   +3 more
openaire   +3 more sources

Discovery and Mapping of an Intracellular Antagonist Binding Site at the Chemokine Receptor CCR2

Molecular Pharmacology, 2014
The chemokine receptor CCR2 is a G protein-coupled receptor that is involved in many diseases characterized by chronic inflammation, and therefore a large variety of CCR2 small molecule antagonists has been developed. On the basis of their chemical structures these antagonists can roughly be divided into two groups with most likely two topographically ...
Zweemer, Annelien J M, Bunnik, Julia, Veenhuizen, Margo, Miraglia, Fabiana, Lenselink, Eelke B, Vilums, Maris, de Vries, Henk, Gibert, Arthur, Thiele, Stefanie, Rosenkilde, Mette M, IJzerman, Adriaan P, Heitman, Laura H   +11 more
openaire   +3 more sources

Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?

Frontiers in Immunology, 2021
Haijia Yu, Yifan Zhan, Yu Haijia
exaly  

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

Frontiers in Immunology, 2022
Yunqing Hua, Fan Guanwei, Jingyu Ni
exaly  

Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

International Journal of Molecular Sciences, 2021
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami   +2 more
exaly  

CCR2 Chemokine Receptor

2007
Masaru Yamamoto, Tsuneya Ikezu
openaire   +1 more source

CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation

Journal of Controlled Release, 2021
Noah Trac, Ailin Zhang, Chun-Peng Liao   +2 more
exaly  

Association of the CCR2 Chemokine Receptor Gene Polymorphism with Myocardial Infarction

Doklady Biological Sciences, 2002
M I, Voevoda, S N, Ustinov, N S, Yudin, M M, Dolgikh, T N, Kuznetsova, V N, Maksimov, I V, Kulikov, A A, Gromov, A V, Shabalin, E V, Semaeva, V F, Kobzev, S R, Baum, V V, Gafarov, S K, Malyutina, A G, Romaschenko, YuP, Nikitin   +15 more
openaire   +2 more sources