Results 211 to 220 of about 33,714 (244)
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Small Molecule Antagonists of the Chemokine Receptor CCR5
Current Topics in Medicinal Chemistry, 2010This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we will focus on the specific medicinal chemistry problems that were faced during the discovery of the molecules.
Rémy C, Lemoine, Jutta, Wanner
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The chemokine receptor CCR5 in the central nervous system
Progress in Neurobiology, 2011The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults.
Sorce S, Myburgh R, Krause KH
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Chemokine receptor CCR5: polymorphism at protein level
Biochemical and Biophysical Research Communications, 2002Polymorphisms in chemokine receptor CCR5 genes have been implicated in HIV disease progression, resistance, or non-progressive infection. Multiple CCR5 transcripts and mRNA diversity have also been identified. This study presents evidence to show that two distinct forms of CCR5 protein, 62 and 42k Da, are present in human lymphocytic cells and monkey ...
Shunji, Suzuki +5 more
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5)
Journal of Natural Products, 2004Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this binding by a small molecule receptor antagonist could lead to a new mode of action agent for HIV-1 and AIDS. Screening of natural product extracts led to the identification of anibamine (1), a novel
Hiranthi, Jayasuriya +14 more
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Chemokine receptor CCR5 polymorphisms and Chagas’ disease cardiomyopathy
Tissue Antigens, 2001Abstract: In this study we investigated the possible role of two CCR5 gene polymorphisms, CCR5Δ32 deletion and CCR5 59029 A→G promoter point mutation, in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease.
Javier Martin
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A Hammerhead Ribozyme Targeted to the Human Chemokine Receptor CCR5
Biochemical and Biophysical Research Communications, 1998The CCR5 chemokine receptor plays a crucial role in the initiation of in vivo HIV infection, acting as a critical coreceptor molecule for primary strains. Individuals with mutations in the CCR5 gene that reduce its level of expression are resistant to HIV-1 infection.
M A, González +5 more
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CCR5: The Receptor That Unlocks the Door for HIV Entry into Cells
The Journal of Immunology, 2022Abstract This Pillars of Immunology article is a commentary on “Identification of a major co-receptor for primary isolates of HIV-1,” a pivotal article written by H. Deng, R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, et al., and published in Nature, in 1996.
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Allosteric effects of antagonists on signalling by the chemokine receptor CCR5
Biochemical Pharmacology, 2007Antagonists of the chemokine receptor, CCR5, may provide important new drugs for the treatment of HIV-1. In this study we have examined the mechanism of action of two functional antagonists of the chemokine receptor CCR5 (UK-396,794, UK-438,235) in signalling and internalisation assays using CHO cells expressing CCR5. Both compounds were potent inverse
Ben, Haworth +4 more
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Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes
European Journal of Biochemistry, 2002Reconstitution of membrane proteins allows their study in a membrane environment that can be manipulated at will. Because membrane proteins have diverse biophysical properties, reconstitution methods have so far been developed for individual proteins on an ad hoc basis.
François, Devesa +7 more
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