Results 221 to 230 of about 33,714 (244)
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Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages
Cellular Immunology, 2004Hypoxia, a decrease in oxygen tension occurring in pathological tissues, has a profound effect on macrophage functions. Here, we provide the first evidence that hypoxia inhibits CCR5 chemokine receptor expression in mouse macrophages. CCR5 was constitutively expressed in macrophages and upregulated by IFNgamma.
Maria Carla, Bosco +3 more
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Soluble chemokine CCR5 receptor is present in human plasma
Immunology Letters, 2005In view of the natural resistance to infection by HIV and occasional delayed clinical manifestation of the disease, as also the fact that the virus is able to enter only cells that express CD4 and a co-receptor, we initiated a search for a soluble co-receptor that might compete with its membrane counterpart.
Alexander, Tsimanis +2 more
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ChemInform Abstract: CCR5 Receptor Antagonist
ChemInform, 2011AbstractReview: 39 refs.
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PRO 140 - A Novel CCR5 Co-Receptor Inhibitor
Recent Patents on Anti-Infective Drug Discovery, 2010Despite an increase in the variety of anti-retroviral agents in the market, there remains a need for novel agents to treat HIV 1 infected individuals, in order to overcome existing problems with adherence, toxicities, drug interactions and viral resistance.
Nadia, Khatib, Satyajit, Das
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HIV Co-Receptor CCR5: Structure and Interactions with Inhibitors
Infectious Disorders - Drug Targets, 2009The CC-chemokine receptor 5 (CCR5), a membrane protein belonging to the G-protein coupled receptor super-family, has been identified as an essential co-receptor for HIV entry into the cells, and small molecules that inhibit HIV entry by targeting CCR5 have been in fast development as antiviral agents.
Ting, Wang, Yong, Duan
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
Neuron, 2023David Rubinsztein +2 more
exaly
[Integrase inhibitors and CCR5 receptor antagonists].
Nihon rinsho. Japanese journal of clinical medicine, 2012Integrase inhibitors and CCR5 receptor antagonists, novel class of antiretrovirals, were introduced into clinical practice in late 2000s. Currently available drugs in these classes, raltegravir and maraviroc, show good tolerability and have little impact on lipid or glucose metabolism compared to traditional classes.
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