Results 11 to 20 of about 1,264,389 (321)

Multiple Targets for Oxysterols in Their Regulation of the Immune System

Cells, 2021
Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system.
Lisa Reinmuth, Cheng-Chih Hsiao, Jörg Hamann, Mette Rosenkilde, John Mackrill   +4 more
doaj   +1 more source

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

Research Progress on NK Cell Receptors and Their Signaling Pathways

Mediators of Inflammation, 2020
Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent
Yingying Chen, Dan Lu, Alexey Churov, Rong Fu   +3 more
doaj   +1 more source

Protein phosphatase 2A regulation of GABAB receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection

Frontiers in Molecular Neuroscience, 2022
One major factor regulating the strength of GABAB receptor signaling and thereby neuronal excitability is the dynamic control of their cell surface expression.
Mohammad Hleihil, Mohammad Hleihil, Karthik Balakrishnan, Dietmar Benke, Dietmar Benke, Dietmar Benke   +5 more
doaj   +1 more source

Cell surface receptors

Current Opinion in Structural Biology, 2000
During the past year, the database of ligand-receptor complexes has essentially doubled. These new results have immeasurably extended and expanded our view of cell surface receptor structure and function. The flood of data has revealed new models for receptor cross-linking, demonstrating the potential stringency of the extracellular requirements for ...
Deller, M, Yvonne Jones, E
openaire   +4 more sources

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

Research Progress of Dendritic Cell Surface Receptors and Targeting

Biomedicines, 2023
Dendritic cells are the only antigen-presenting cells capable of activating naive T cells in humans and mammals and are the most effective antigen-presenting cells.
Chunyu Tong, Yimin Liang, Xianle Han, Zhelin Zhang, Xiaohui Zheng, Sen Wang, Bocui Song   +6 more
doaj   +1 more source

Aptamers for Targeted Drug Delivery

Pharmaceuticals, 2010
Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences. They are typically generated by an iterative screening process of complex nucleic acid libraries employing a ...
Partha Ray, Rebekah R. White
doaj   +1 more source

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background A hallmark of heart failure is cardiac fibrosis, which results from the injury‐induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix.
Nicholas W. Chavkin, Soichi Sano, Ying Wang, Kosei Oshima, Hayato Ogawa, Keita Horitani, Miho Sano, Susan MacLauchlan, Anders Nelson, Karishma Setia, Tanvi Vippa, Yosuke Watanabe, Jeffrey J. Saucerman, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh   +15 more
doaj   +1 more source

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly [PDF]

, 2010
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters.
A Radu Aricescu, AG Leslie, AJ McCoy, AR Aricescu, BC Cunningham, C Litterst, CD Thanos, CJ Vearing, CN Chin, D Nikolov, DP Zelinski, E Yvonne Jones, EB Pasquale, EB Pasquale, Elena Seiradake, Eph Nomenclature Committee, EV Bocharov, F Grueninger-Leitch, FM Smith, G Shaw, Geoff Sutton, H Miao, IW Davis, J Egea, J Wykosky, JD Bendtsen, JE Chrencik, JP Himanen, JP Himanen, JP Himanen, JP Himanen, JP Himanen, K Diedrichs, K Miura, Karl Harlos, KT Lin, M Landau, MA Cooper, MS Kinch, N Carter, ND Zantek, NW Gale, P Emsley, P Gouet, PD Adams, PJ Reeves, RA Lindberg, RF Carvalho, S Davis, S Orsulic, SH Wimmer-Kleikamp, T Nagai, TA Bowden, TS Walter, TS Walter, VT Chang, W Kabsch, YG Lin   +57 more
core   +1 more source