Results 71 to 80 of about 636,621 (274)

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. [PDF]

, 2017
Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F ...
Jardetzky, Theodore S, Komives, Elizabeth A, Lamb, Robert A, Leser, George P, Liu, Shiheng, Salafsky, Joshua, Wong, Joyce JW, Young, Tracy A, Zhang, Jiayan, Zhou, Z Hong   +9 more
core   +2 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Palmitoylation of the canine histamine H2 receptor occurs at Cys305 and is important for cell surface targeting [PDF]

, 2001
To determine the presence and functional role of the histamine H2 receptor (H2R) palmitoylation, a receptor with a Cys305 to Ala (A305 receptor) mutation was generated. Wild-type (WT) and A305 receptors were tagged at their N-termini with a hemagglutinin
Anai, Motonobu, Asano, Tomoichiro, Fujishiro, Midori, Fukushima, Yasushi, Funaki, Makoto, Inukai, Kouichi, Ishikawa, Takashi, Nagai, Ryozo, Ogihara, Takehide, Omata, Masao, Onishi, Yukiko, Ono, Hiraku, Saitoh, Toshihito, Sakoda, Hideyuki, Takata, Kuniaki   +14 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Dynamics of cooperativity in chemical sensing among cell-surface receptors [PDF]

, 2011
Cooperative interactions among sensory receptors provide a general mechanism to increase the sensitivity of signal transduction. In particular, bacterial chemotaxis receptors interact cooperatively to produce an ultrasensitive response to chemoeffector concentrations.
arxiv   +1 more source

Pleiotropy enables specific and accurate signaling in the presence of ligand cross talk [PDF]

Phys. Rev. E 103, 042401 (2021), 2019
Living cells sense their environment through the binding of extra-cellular molecular ligands to cell surface receptors. Puzzlingly, vast numbers of signaling pathways exhibit a high degree of cross talk between different signals whereby different ligands act through the same receptor or shared components downstream.
arxiv   +1 more source

Expression of interleukin 2 receptors on activated human B cells. [PDF]

, 1984
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
Bongiovanni, KF, Depper, JM, Goldman, CK, Greene, WC, Korsmeyer, SJ, Leonard, WJ, Robb, RJ, Sharrow, SO, Waldmann, TA   +8 more
core  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Quantification of the Surface Expression of G Protein-coupled Receptors Using Intact Live-cell Radioligand Binding Assays

Bio-Protocol, 2020
G protein-coupled receptors (GPCRs) are the most structurally diverse family of signaling proteins and regulate a variety of cell function. For most GPCRs, the cell surface is their functional destination where they are able to respond a wide range of ...
Xin Xu, Guangyu Wu
doaj   +1 more source

Receptor crosstalk improves concentration sensing of multiple ligands [PDF]

Phys. Rev. E 99, 022423 (2019), 2018
Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems leading to crosstalk between different receptors.
arxiv   +1 more source