Results 211 to 220 of about 176,440 (265)

Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

de Boer B, Lamme TD, Verdwaald K, Medina SS, Németh CG, Elfrink EM, Smit MJ, de Esch IJ, Schafer CT.   +8 more
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Chemokines and chemokine receptors in rheumatoid arthritis

Seminars in Immunology, 2003
Chemokines are chemotactic cytokines involved in a number of pathological processes, including inflammatory conditions. Chemokines play a role in the pathogenesis of various inflammatory diseases. Based on a burgeoning body of literature, RA was chosen as a prototype to discuss this issue. In this review, the authors give a detailed introduction to the
Zoltan Szekanecz, Alisa E Koch
exaly   +3 more sources

Chemokines, chemokine receptors and hematopoiesis

Immunological Reviews, 2000
Hematopoiesis during steady state conditions is regulated and finely tuned by a network of cytokines and their effects on hematopoietic stem and progenitor cells and on accessory cells that influence the stem and progenitor cells. Amongst the numerous cytokines implicated in this regulation are members of the CC, CXC and C family of chemokines.
B S, Youn, C, Mantel, H E, Broxmeyer
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Chemokine receptors

Cytokine & Growth Factor Reviews, 2001
Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology ...
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Chemokine–Chemokine Receptors in Cancer Immunotherapy

Immunotherapy, 2008
A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in human biology, particularly immunity. Specific tissue microenvironments express distinct chemokines and both hematopoietic and nonhematopoietic cells have receptor expression profiles that permit
J. Stewart, Trina, J. Smyth, Mark
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Chemokines, Chemokine Receptors and Allergy

International Archives of Allergy and Immunology, 2001
Chemokines are a group of cytokines that are responsible for the influx of blood cells, including T and B lymphocytes, monocytes, neutrophils, eosinophils and basophils, in allergic and other inflammatory conditions. They function as G protein-coupled chemotactic factors which also activate the cells with which they interact.
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Chemokines and Chemokine Receptors in Scleroderma

International Archives of Allergy and Immunology, 2006
Scleroderma is a connective tissue disease with unknown etiology characterized by excessive deposition of extracellular matrix in the skin. Cellular infiltrates of certain immune cells and proinflammatory mediators are suggested to play a crucial role in cutaneous fibrosis, forming complicated networks between fibroblasts and immune cells via cell-cell
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Chemokines, chemokine receptors and pain

Trends in Immunology, 2005
Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimuli, such as light touch, become ...
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Chemokines and Chemokine Receptors

1999
Classic chemoattractants include complement components, formyl peptides and leukotriene B4. In addition, various cytokines are able to elicit directional migration of leukocytes. While molecules such as monocyte-colony stimulating factor or tumor necrosis factor also exert chemotactic activity, the main chemotactic cytokines are a superfamily of ...
A. Mantovani, P. Allavena, C. Garlanda, S. Ramponi, C. Paganini, A. Vecchi, S. Sozzani   +6 more
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Targeting chemokines and chemokine receptors with antibodies

Drug Discovery Today: Technologies, 2012
Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Klarenbeek, A., Maussang, D., Blanchetot, C., Saunders, M., van der Woning, S.P., Smit, M.J., Haard, H., Hofman, E.   +7 more
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