Results 71 to 80 of about 16,141 (203)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

An immunochemical approach to model and long-term suppression of depressive and anxiety behaviour

, 2006
The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin- 4 play a significant role in the suppression and induction of depressive and anxiety states.
Obukhova, Maria F., Shmalgausen, Elena V., Danilova, Raisa A., Ashmarin, Igor P., Belopolskaya, Maria V., Rud'ko, Olga I.   +5 more
core  

Gallbladder‐Related Adverse Events With Semaglutide 2.4 mg: Pooled Analysis of Placebo‐Controlled STEP Trials

Diabetes, Obesity and Metabolism, EarlyView.
Mika Ukkonen, Antti Kivivuori, Peter Starckjohann, Pekka Lammi, Anna Junttila, Valtteri Panula   +5 more
wiley   +1 more source

Single‐nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Gonadotropin‐releasing hormone (GnRH) is a central regulator of vertebrate reproduction regulating pituitary gonadotropins. In zebrafish, GnRH3 serves as the hypophysiotropic isoform. Its neurons develop by migrating from the nasal placode to the hypothalamus, forming several distinct subpopulations along the migratory path.
Yalong Sun, Matan Golan, Yonathan Zohar, Xiaoxuan Fan, Nilli Zmora   +4 more
wiley   +1 more source

Effects of Egg White Powder Supplementation on Nutritional Status, Biochemical Profile, and Oxidative Stress Markers in Diabetic Hemodialysis Patients; A Double‐Blind Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Protein‐energy wasting (PEW) and oxidative stress (OS) frequently occur as complications in patients undergoing hemodialysis (HD), especially among those diagnosed with type 2 diabetes mellitus (T2DM). Egg white powder (EWP) is a low‐phosphorus, high‐ biological value protein source that may help improve nutritional and ...
Arvin Babaei, Hamta Abdollah Niya, Soudabeh Hamedi‐Shahraki, Javid Safa, Ali Tarighat‐Esfanjani   +4 more
wiley   +1 more source

New Insights in the Design of Bioactive Peptides and Chelating Agents for Imaging and Therapy in Oncology

Molecules, 2017
Many synthetic peptides have been developed for diagnosis and therapy of human cancers based on their ability to target specific receptors on cancer cell surface or to penetrate the cell membrane.
Anna Lucia Tornesello, Luigi Buonaguro, Maria Lina Tornesello, Franco Maria Buonaguro   +3 more
doaj   +1 more source

Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice

Nature Communications
Chronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu, Ying Kong, Xiao-Wen Meng, Ke Peng, Yang Yu, Shao-Yong Song, Yu-Fan Yang, Hua-Yue Liu, Guang-Yin Xu, Fu-Hai Ji   +9 more
doaj   +1 more source

Antidepressant‐ and Anxiolytic‐Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates

Background The study aims to explore the potential antianxiety effect of Froriepia subpinnata, a native plant in northern Iran, and it is considered an antiflatulent, appetizing, antiseptic, antispasmodic, and diuretic.
Mohammad R. Samandari‐Bahraseman, Banafsheh Khaleghdoust, Keyvan Esmaeilzadeh‐Salestani, Evelin Loit, Nima Hatami, Leila Elyasi, Saeed Esmaeili‐Mahani, Jaanus Harro, Manijeh Dogani   +8 more
core   +1 more source

Expression of the Transcription Factor Egr-1 in Pancreatic Acinar Cells Following Stimulation of Cholecystokinin or Gαq-Coupled Designer Receptors

Cellular Physiology and Biochemistry, 2014
Backgound/Aims: The injection of cerulein, an analogue of the pancreatic secretagogue cholecystokinin (CCK), induces acute pancreatitis in mice that is accompanied by the synthesis of the transcription factor Egr-1.
Anke Kaufmann, Oliver G. Rössler, Gerald Thiel   +2 more
doaj   +1 more source

Cholecystokinin and neurotensin inversely modulate excitatory synaptic transmission in the parabrachial nucleus in vitro

Cholecystokinin and neurotensin are present in fibres innervating the parabrachial nucleus and have previously been shown to modulate the flow of visceral afferent information through the parabrachial nucleus to the cortex in the rat. This study examined

core   +1 more source