Results 81 to 90 of about 30,225 (238)
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, Volume 13, Issue 29, 22 May 2026.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang +9 more
wiley +1 more source
G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets [PDF]
, 2014 It is becoming evident that nutrients and metabolic intermediates derived from such nutrients regulate cellular function by activating a number of cell-surface G-protein coupled receptors (GPCRs).
Brian D. Hudson +6 more
core +2 more sources
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.Consuming carbohydrates last, after protein and vegetables, is associated with reduced postprandial glucose excursions in individuals with diabetes. This systematic review of six studies suggests macronutrient ordering may be a simple, effective strategy to improve glycaemic control.
Rebecca McKenzie +3 more
wiley +1 more source
Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea
JPGN Reports, Volume 7, Issue 2, Page 242-246, May 2026.Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno +7 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Molecules, 2017 Many synthetic peptides have been developed for diagnosis and therapy of human cancers based on their ability to target specific receptors on cancer cell surface or to penetrate the cell membrane.
Anna Lucia Tornesello +3 more
doaj +1 more source
Pediatric Pulmonology, Volume 61, Issue 5, May 2026.ABSTRACT Background In people with cystic fibrosis (pwCF), identification of exocrine pancreatic insufficiency (EPI) is essential to prevent steatorrhea and, if not managed actively, can lead to catastrophic consequences. Fecal elastase‐1 (FE‐1) is a widely used test to screen for EPI in cystic fibrosis (CF).
Senthilkumar Sankararaman +3 more
wiley +1 more source
Nature CommunicationsChronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu +9 more
doaj +1 more source
Endocannabinoid Release Modulates Electrical Coupling between CCK Cells Connected via Chemical and Electrical Synapses in CA1 [PDF]
, 2011 Electrical coupling between some subclasses of interneurons is thought to promote coordinated firing that generates rhythmic synchronous activity in cortical regions.
Afia B. Ali, Jonathan Iball
core +2 more sources