Results 81 to 90 of about 437,706 (248)

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Zablocki, Krzysztof, Elżbieta Krasowska, Krasowska Elżbieta, Gorecki, Dariusz C., Swinny, Jerome D., Dariusz C Górecki, Swinny Jerome D., Zabłocki Krzysztof, Jerome D Swinny, Krasowska, Elzbieta, Górecki Dariusz C., Krzysztof Zabłocki   +11 more
core   +2 more sources

Sensing of luminal contents and downstream modulation of GI function

JGH Open
The luminal environment is rich in macronutrients coming from our diet and resident microbial populations including their metabolites. Together, they have the capacity to modulate unique cell surface receptors, known as G‐protein coupled receptors (GPCRs)
Kiran Devi Dontamsetti, Laura Camila Pedrosa‐Suarez, Rubina Aktar, Madusha Peiris   +3 more
doaj   +1 more source

Amylin: A Multi‐Functional Pancreatic Hormone—A Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Amylin is a pancreatic beta‐cell hormone that sits at a systems hub connecting key aspects of energy metabolism. Amylin physiologically controls satiation, slows gastric emptying and limits postprandial glucagon release, while its actions also link homeostatic eating controls with reward driven behaviours via defined central nervous system ...
Christelle Le Foll, Thomas A. Lutz
wiley   +1 more source

Cholecystokinin stimulates aldosterone secretion from dispersed rat zona glomerulosa cells, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase-dependent cascade [PDF]

, 2001
Cholecystokinin is a regulatory peptide, that acts through two subtypes of receptors, 1 and 2. RT-PCR demonstrated the expression of both cholecystokinin receptors 1 and 2 genes in the zona glomerulosa, but not the zona fasciculata-reticularis, of rat ...
TORTORELLA, CINZIA, MALENDOWICZ L. K., NOWAK M., MAJCHRZAK M., NUSDORFER G. G., GOTTARDO L.   +5 more
core  

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Cholecystokinin- and Melatonin-receptors in human and rat salivary glands [PDF]

, 2010
Recent observations of ours show the rat parotid gland to respond, in vivo, to gastrin, cholecystokinin and melatonin with protein secretion, without any accompanying overt fluid secretion.
LOY, FRANCESCO, RIVA A, GRUNDITZ T, EKSTROM J, HELANDER H., ÇEVIK ARAS H   +5 more
core  

Experimental pancreatitis is mediated by low-affinity cholecystokinin receptors that inhibit digestive enzyme secretion [PDF]

, 1989
Rats infused with a supramaximally stimulating dose of the cholecystokinin (CCK) analog caerulein develop acute edematous pancreatitis. Using CCK-JMV-180, a recently developed CCK analog that acts as an agonist at high-affinity CCK receptors but ...
Printz, H, Saluja, M, Saluja, A K, Steer, M L, Zavertnik, A, Sengupta, A   +5 more
core   +1 more source

Current Status of Radiopharmaceuticals for the Theranostics of Neuroendocrine Neoplasms

Pharmaceuticals, 2017
: Nuclear medicine plays a pivotal role in the management of patients affected by neuroendocrine neoplasms (NENs). Radiolabeled somatostatin receptor analogs are by far the most advanced radiopharmaceuticals for diagnosis and therapy (radiotheranostics ...
Melpomeni Fani, Petra Kolenc Peitl, Irina Velikyan   +2 more
doaj   +1 more source

Continuous darkness is associated with improved growth performance during a high‐temperature period and sex‐specific modulation of early gonadal development in juvenile yellowtail (Seriola quinqueradiata)

Journal of Fish Biology, EarlyView.
Abstract Selective breeding of yellowtail (Seriola quinqueradiata) is expanding in Japan, increasing the demand for practical reproductive control tools in commercial aquaculture to reduce genetic risks from escapees. Slowing early gonadal development through environmental manipulation may support future sterilization strategies, particularly when ...
Yuya Hasegawa, Kiko Shibata, Taiga Abe, Takurou Hotta   +3 more
wiley   +1 more source

Utilization of Knockout Mice to Examine the Potential Role of Gastric Histamine H2-Receptors in Menetrier’s Disease

Journal of Pharmacological Sciences, 2003
Menetrier’s disease is characterized by giant gastric folds with foveolar hyperplasia and cystic dilatation, hypoproteinemia, and enhanced mucus secretion. The etiology remains unresolved and an effective treatment has yet to be established. Here we show
Toshiki Ogawa, Kazuhiko Maeda, Shunsuke Tonai, Takashi Kobayashi, Takeshi Watanabe, Susumu Okabe   +5 more
doaj   +1 more source