Results 1 to 10 of about 2,387,238 (359)

Acetylcholine and cholinergic receptors [PDF]

Brain and Neuroscience Advances, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic acetylcholine receptors, and some brief comments on possible advances in the near future.
D. Brown
openaire   +5 more sources

A sex-specific effect of M4 muscarinic cholinergic autoreceptor deletion on locomotor stimulation by cocaine and scopolamine [PDF]

Frontiers in Molecular Neuroscience
ObjectiveAcetylcholine modulates the activity of the direct and indirect pathways within the striatum through interaction with muscarinic M4 and M1 receptors.
Anna Berezovskaia, Anna Berezovskaia, Morgan Thomsen, Morgan Thomsen, Morgan Thomsen, Anders Fink-Jensen, Anders Fink-Jensen, Anders Fink-Jensen, Gitta Wörtwein, Gitta Wörtwein, Gitta Wörtwein   +10 more
doaj   +2 more sources

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

Journal of Neuroscience, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McIntosh, J. Michael, McKinney, Sheri, Miwa, Julie M., Patzlaff, Natalie E., Steele, Andrew D.   +8 more
core   +2 more sources

Biological Functions of Keratinocyte Cholinergic Receptors

Journal of Investigative Dermatology Symposium Proceedings, 1997
Human epidermal keratinocytes possess cholinergic enzymes, which synthesize and degrade acetylcholine, and express both nicotinic and muscarinic classes of cholinergic receptors on their cell surfaces. These receptors bind acetylcholine and initiate cellular response.
S. Grando
openaire   +4 more sources

Beta-adrenergic and M-cholinergic receptor interactions in the pathogenesis of bronchial obstructive pulmonary diseases [PDF]

Клиническая практика, 2020
The crosstalk between the beta-2-adrenoceptor and M- cholinoreceptor systems in the airways plays one of the main roles in the pathogenesis of bronchoobstructive diseases.
Anna V. Eremenko, Kirill A. Zykov
doaj   +1 more source

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

Nature Communications, 2023
The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer   +11 more
doaj   +1 more source

Nanoscopic distribution of VAChT and VGLUT3 in striatal cholinergic varicosities suggests colocalization and segregation of the two transporters in synaptic vesicles [PDF]

Frontiers in Molecular Neuroscience, Frontiers Media, 2022, 15, 2022
Striatal cholinergic interneurons (CINs) use acetylcholine (ACh) and glutamate (Glut) to regulate the striatal network since they express vesicular transporters for ACh (VAChT) and Glut (VGLUT3). However, whether ACh and Glut are released simultaneously and/or independently from cholinergic varicosities is an open question.
arxiv   +1 more source

Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish Nothobranchius furzeri

Brain Sciences, 2020
Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals are considered necessary for ensuring the survival of cholinergic neurons.
Paolo de Girolamo, Adele Leggieri, Antonio Palladino, Carla Lucini, Chiara Attanasio, Livia D’Angelo   +5 more
doaj   +1 more source

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

Frontiers in Immunology, 2021
Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the ...
Namrita Halder, G. Lal
semanticscholar   +1 more source

Effect of gallamine on cholinergic receptors [PDF]

Canadian Anaesthetists’ Society Journal, 1970
Gallamine triethiodide causes tachycardia thought to be due to a specific vagolytic action. Recently, Brown and Crout have shown that gallamine may cause increased inotropic and chronotropic activity due to the release of catecholamines from cardiac sympathetic nerves.
John T. Hamilton, Flora J. Rathbun
openaire   +3 more sources