Results 41 to 50 of about 83,987 (167)
Рациональная фармакотерапия в кардиологии, 2015 Aim. To identify the most promising epitopes that simulate various sites β1-adrenergic and M2-cholinergic receptors, and to evaluate their possible contribution to the development and maintenance of cardiac arrhythmias, particularly idiopathic ...
M. M. Rogova +8 more
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Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide. [PDF]
PLoS ONE, 2013 Oxidative stress is implicated in the pathogenesis of neurodegenerative disorders and hydrogen peroxide (H2O2) plays a central role in the stress. Huprines, a group of potent acetylcholinesterase inhibitors (AChEIs), have shown a broad cholinergic ...
Marta Pera +5 more
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European Journal of Pharmacology, 1974 This study shows that (a) the slopes of dose-response curves of bromoacetylcholine (BrACh) and acetylcoline (ACh) were the same; (b) the dose-response curves of BrACh to contract superfused chick biventer cervicis and frog rectus abdominis muscles were shifted to the right by d-tubocurarine in a parallel fashio; and (c) the responses of BrACh were not ...
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida 32610, U.S.A. +1 more
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The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundThe effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model.MethodsCatheters were placed into the intrathecal space of male Sprague-Dawley
In Ji Kim +3 more
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The central cholinergic system as a therapeutic target in Parkinson's disease
Journal of Parkinson’s DiseaseThe central cholinergic system plays a crucial role in neural communication and physiological regulation, mediated by acetylcholine (ACh) and cholinergic receptors in the central nervous system (CNS). In this review, we explore the extensive distribution
Sean J Miller +4 more
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Frontiers in Cellular Neuroscience, 2016 The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao +8 more
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Muscarinic cholinergic receptors in rabbit retina
Journal of Pharmacy and Pharmacology, 1985 Abstract Binding sites with high affinity and specificity for [3 H]-quinuclidinyl benzilate are present in rabbit retinal homogenates. Only one set of binding sites was detected with an apparent dissociation constant of 2.13 times 10−10 M and a density of 59.2 fmol mg−1 of protein.
M J, Neal, C, Dawson
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Frontiers in Behavioral Neuroscience, 2019 The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross +2 more
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Cholinergic receptors in aging and Alzheimer's disease
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1986 Although Alzheimer's disease (AD) is a disorder involving multiple neurotransmitter systems, the basal forebrain cholinergic system (Ch system) is severely and consistently affected in this condition. In both animals and man, the nature of age-associated alterations in the Ch system is unclear. In addition, available studies of cholinergic receptors in
P J, Whitehouse, K S, Au
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Pain Research and Management, 2018 Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways.
Zainul Amiruddin Zakaria +8 more
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