Results 91 to 100 of about 79,884 (218)

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

open access: yesNeuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai   +3 more
wiley   +1 more source

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

open access: yesChemistryOpen, EarlyView.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya   +8 more
wiley   +1 more source

Nipocalimab Dose Selection in Generalized Myasthenia Gravis

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Model‐Informed Nipocalimab Dose Selection for Generalized Myasthenia Gravis. ABSTRACT Nipocalimab is a fully human immunoglobulin G (IgG)1 monoclonal antibody (mAb) designed to selectively block the IgG binding site of neonatal fragment crystallizable receptor (FcRn) to inhibit IgG recycling and decrease circulating IgG, including pathogenic IgG ...
Belén Valenzuela   +8 more
wiley   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese   +13 more
wiley   +1 more source

Spasmodic Dysphonia

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Frozen in Addiction: A New Wave of Drug‐Induced Movement Disorders?

open access: yes
Movement Disorders, EarlyView.
Christos Ganos   +12 more
wiley   +1 more source

Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The purpose of this study is to identify the earliest appearing auditory electrophysiological indicators that change with age progression in young adults with normal hearing, and to analyze the frequency distribution patterns of these markers in the cochlear.
Min‐Fei Qian   +6 more
wiley   +1 more source

Longitudinal Trajectory of Multimodal Markers in a Patient with Isolated REM Sleep Behavior Disorder

open access: yes
Movement Disorders, EarlyView.
Seohee Choi   +7 more
wiley   +1 more source

Prevalence, Comorbidities, and Current Management of Chronic Spontaneous Urticaria in Japan: Retrospective Claims Database Study

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Chronic spontaneous urticaria (CSU) affects 0.5%–1.0% of the population worldwide. However, information on the prevalence, comorbidities, and treatment patterns of CSU in Japan is limited. This observational study consisted of a cross‐sectional and longitudinal part.
Atsushi Fukunaga   +3 more
wiley   +1 more source

Progress in the study of dioecy in Mexican cycad species and its implications for conservation

open access: yesPlant Species Biology, EarlyView.
Cycads are endangered dioecious plants of great ornamental value that have a long period of sexual maturity. Therefore, it is crucial to have methods for early sex determination that can help to develop effective strategies for their conservation. Abstract Dioecy is a system of sexual reproduction in plants, characterized by the spatial separation of ...
Lourdes Georgina Iglesias Andreu   +2 more
wiley   +1 more source

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