Results 111 to 120 of about 140,582 (304)

Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats [PDF]

, 2017
Rationale Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in
A Bari, A Castañé, BN Armbruster, D Dautan, EA Schilman, ER Murphy, ES Robinson, G Paxinos, GM Alexander, HD Brown, J Groenewegen, J Wess, JN Rouder, JW Dalley, K Guillem, KM Turner, LA Bradfield, M Baviera, M Bentivoglio, M Carli, M Kimura, M Pezze, ME Ragozzino, N Amitai, N Matsumoto, NM Doig, P Aldrin-Kirk, RD Rogers, S Kinomura, SV Mahler, T Minamimoto, T Robbins, TJ Stachniak, TW Faust, V Boulougouris, Y Chudasama, Y Smith   +36 more
core   +2 more sources

Almond (Amygdalus communis L.) Peptides Improve Scopolamine‐Induced Learning and Memory Impairment in Mice

Food Safety and Health, EarlyView.
Figure Schematic showing the improvement of almond peptides on learning and memory impairment induced by scopolamine in mice. Almond peptides (APs) could improve the learning and memory in scopolamine‐induced mice by maintaining cholinergic system homeostasis and regulating Nrf2/Keap1 signaling pathway, via activating the Nrf2 transcription factor and ...
Xin Shang, Wenjing Gao, Caiyun Zhao, Bin Li, Jintian Guo, Jingteng Wang, Minwei Zhang, Yinghua Fu   +7 more
wiley   +1 more source

Muscarinic cholinergic receptors in rabbit retina

Journal of Pharmacy and Pharmacology, 1985
Abstract Binding sites with high affinity and specificity for [3 H]-quinuclidinyl benzilate are present in rabbit retinal homogenates. Only one set of binding sites was detected with an apparent dissociation constant of 2.13 times 10−10 M and a density of 59.2 fmol mg−1 of protein.
M J, Neal, C, Dawson
openaire   +2 more sources

Cognition in menopausal women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar, Jharna Mahajan (Bhanushali), Anuradha P. Mahto, Satish Khadilkar   +3 more
wiley   +1 more source

Artificial sensory and motor nervous systems enabled by bioinspired nanowire heterostructure synapse

InfoMat, EarlyView.
A p‐i‐n heterostructured junction synaptic transistor was fabricated, composed of poly(3‐hexylthiophene‐2,5‐diyl) nanowire thin‐film/poly(methyl methacrylate)/ZnO nanowires (PZJ STs), which can emulate biological sensory and motor nervous systems.
Lu Yang, Shuo Zhang, Yue Li, Hong Han, Qingwen Cheng, Zhipeng Xu, Ning Wu, Wentao Xu   +7 more
wiley   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Cholinergic receptor labelling specific irreversible binding of bromoacetylcholine to cholinergic receptors at neuromuscular junctions

European Journal of Pharmacology, 1974
This study shows that (a) the slopes of dose-response curves of bromoacetylcholine (BrACh) and acetylcoline (ACh) were the same; (b) the dose-response curves of BrACh to contract superfused chick biventer cervicis and frog rectus abdominis muscles were shifted to the right by d-tubocurarine in a parallel fashio; and (c) the responses of BrACh were not ...
Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida 32610, U.S.A., Chiou, C.Y.   +1 more
openaire   +3 more sources

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep

eLife, 2016
Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (REM) sleep and arousal. Using transgenic mice in which channelrhdopsin-2 is selectively expressed in cholinergic neurons, we show ...
Kun-Ming Ni, Xiao-Jun Hou, Ci-Hang Yang, Ping Dong, Yue Li, Ying Zhang, Ping Jiang, Darwin K Berg, Shumin Duan, Xiao-Ming Li   +9 more
doaj   +1 more source

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core