Results 161 to 170 of about 2,364,275 (293)

Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy

Journal of Sleep Research, EarlyView.
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash, Ishani Shah, Guohao Ni, Sridhar Vasudevan, Aarti Jagannath, Russell G. Foster   +5 more
wiley   +1 more source

Induction of chronic prostatitis does not alter the innate contractile properties of the prostate or urethra in rats. [PDF]

Sci Rep
Aydogdu O, Black G, Aronsson P, Carlsson T, Winder M.   +4 more
europepmc   +1 more source

Sleep‐related hypermotor epilepsy—No longer controversial

Epilepsia, EarlyView.
Francesca Bisulli, Samuel F. Berkovic, Ingrid E. Scheffer, Edouard Hirsch, Lino Nobili, Federica Provini, Paolo Tinuper, Luca Vignatelli   +7 more
wiley   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, EarlyView.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source

An endogenous cholinergic system controls electrical conduction in the heart. [PDF]

Eur Heart J
Xie D, Xiong K, Dong N, Wang G, Zou Q, Shao B, Chen Z, Wang L, Kong Y, Wang X, Su X, Bai W, Yang J, Liu Y, Zhou B, Chen YH.   +15 more
europepmc   +1 more source

Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission

British Journal of Pharmacology, 2008
R. Exley, S. Cragg
semanticscholar   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse. [PDF]

Pharmaceuticals (Basel)
Tsimpili H, Zoidis G.
europepmc   +1 more source

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Research progress in myocardial function and diseases related to muscarinic acetylcholine receptor (Review). [PDF]

Int J Mol Med
Shen C, Zuo Q, Shao Z, Lin Y, Chen S.
europepmc   +1 more source