Results 11 to 20 of about 2,347,334 (218)

Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy

Frontiers in Pharmacology, 2018
Nicotinic acetylcholine receptors (nAChRs) expressed on the cell plasma membrane are ligand-gated ion channels mediating fast synaptic transmission, regulating neurotransmitter and cytokine release and supporting the viability of many cell types.
Kateryna Uspenska, Olena Lykhmus, Maria Obolenskaya, Stephanie Pons, Uwe Maskos, Serhiy Komisarenko, Maryna Skok   +6 more
doaj   +1 more source

Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence

Acta Pharmacologica Sinica, 2019
Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors (nAChRs) and interferes with physiological function of the cholinergic system ...
C. Xiao, Chunyi Zhou, Jin-hong Jiang, Cui Yin   +3 more
semanticscholar   +1 more source

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.

Cancer Discovery, 2018
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been ...
Bernhard W. Renz, Bernhard W. Renz, Takayuki Tanaka, Takayuki Tanaka, Masaki Sunagawa, R. Takahashi, Zhengyu Jiang, M. Macchini, Z. Dantes, G. Valenti, Ruth A. White, M. Middelhoff, M. Ilmer, P. Oberstein, M. Angele, Huan Deng, Huan Deng, Y. Hayakawa, Y. Hayakawa, C. Westphalen, C. Westphalen, J. Werner, H. Remotti, M. Reichert, Yagnesh H. Tailor, K. Nagar, R. Friedman, A. Iuga, K. Olive, T. Wang   +29 more
semanticscholar   +1 more source

Acetylcholine and spinal locomotor networks: The insider

Physiological Reports, 2021
This article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine (ACh) in controlling the operation of locomotor neural networks within the spinal cord. This cholinergic system has the particularity of
Théo Mille, Camille Quilgars, Jean‐René Cazalets, Sandrine S. Bertrand   +3 more
doaj   +1 more source

Cholinergic Regulation of Hippocampal Theta Rhythm

Biomedicines, 2022
Cholinergic regulation of hippocampal theta rhythm has been proposed as one of the central mechanisms underlying hippocampal functions including spatial memory encoding.
Zhenglin Gu, Jerrel L. Yakel
doaj   +1 more source

Development of fetal nicotine and muscarinic receptors in utero

Brazilian Journal of Medical and Biological Research, 2007
The role of acetylcholine in the central and peripheral nervous systems is well established in adults. Cholinergic modulation of vascular functions and body fluid balance has been extensively studied.
C. Mao, J. Lv, H. Li, Y. Chen, J. Wu, Z. Xu   +5 more
doaj   +1 more source

The involvement of cholinergic neurons in the spreading of tau pathology

Frontiers in Neurology, 2013
Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease. Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the ...
Diana eSimon, Diana eSimon, Felix eHernandez, Felix eHernandez, Jesus eAvila, Jesus eAvila   +5 more
doaj   +1 more source

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease

Journal of Neuroscience, 2016
Over the last decade, striatal cholinergic interneurons (ChIs) have reemerged as key actors in the pathophysiology of basal-ganglia-related movement disorders. However, the mechanisms involved are still unclear.
Samira Ztaou, N. Maurice, J. Camon, G. Guiraudie-Capraz, L. Kerkerian-Le Goff, C. Beurrier, M. Liberge, M. Amalric   +7 more
semanticscholar   +1 more source

Non-neuronal regulation and repertoire of cholinergic receptors in organs

Biomolecular Concepts, 2010
Many studies on the cholinergic pathway have indicated that cholinergic receptors, which are widely expressed in various cells, play an important role in all body organs.
Sato Tsuyoshi, Chida Dai, Iwata Takanori, Usui Michihiko, Hatori Kouki, Abe Takahiro, Takeda Shu, Yoda Tetsuya   +7 more
doaj   +1 more source

Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections

mSphere, 2019
Acetylcholine modulates the virulence of Candida albicans and regulates an appropriate immune response to infection in a Galleria mellonella infection model. Indeed, the evidence suggests that C.
Christopher Nile, Monica Falleni, Daniela Cirasola, Abeer Alghamdi, Oliver F. Anderson, Christopher Delaney, Gordon Ramage, Emerenziana Ottaviano, Delfina Tosi, Gaetano Bulfamante, Giulia Morace, Elisa Borghi   +11 more
doaj   +1 more source