Results 11 to 20 of about 2,364,275 (293)

Biological Functions of Keratinocyte Cholinergic Receptors

Journal of Investigative Dermatology Symposium Proceedings, 1997
Human epidermal keratinocytes possess cholinergic enzymes, which synthesize and degrade acetylcholine, and express both nicotinic and muscarinic classes of cholinergic receptors on their cell surfaces. These receptors bind acetylcholine and initiate cellular response.
S. Grando
openaire   +4 more sources

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

Frontiers in Immunology, 2021
Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the ...
Namrita Halder, G. Lal
semanticscholar   +1 more source

Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence

Acta Pharmacologica Sinica, 2019
Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors (nAChRs) and interferes with physiological function of the cholinergic system ...
C. Xiao, Chunyi Zhou, Jin-hong Jiang, Cui Yin   +3 more
semanticscholar   +1 more source

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness.

Cancer Discovery, 2018
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been ...
Bernhard W. Renz, Bernhard W. Renz, Takayuki Tanaka, Takayuki Tanaka, Masaki Sunagawa, R. Takahashi, Zhengyu Jiang, M. Macchini, Z. Dantes, G. Valenti, Ruth A. White, M. Middelhoff, M. Ilmer, P. Oberstein, M. Angele, Huan Deng, Huan Deng, Y. Hayakawa, Y. Hayakawa, C. B. Westphalen, C. B. Westphalen, J. Werner, H. Remotti, M. Reichert, Yagnesh H. Tailor, K. Nagar, R. Friedman, A. Iuga, K. Olive, T. Wang   +29 more
semanticscholar   +1 more source

Development of fetal nicotine and muscarinic receptors in utero

Brazilian Journal of Medical and Biological Research, 2007
The role of acetylcholine in the central and peripheral nervous systems is well established in adults. Cholinergic modulation of vascular functions and body fluid balance has been extensively studied.
C. Mao, J. Lv, H. Li, Y. Chen, J. Wu, Z. Xu   +5 more
doaj   +1 more source

The involvement of cholinergic neurons in the spreading of tau pathology

Frontiers in Neurology, 2013
Long time ago, it was described the selective loss of cholinergic neurons during the development of Alzheimer disease. Recently, it has been suggested that tau protein may play a role in that loss of cholinergic neurons through a mechanism involving the ...
Diana eSimon, Diana eSimon, Felix eHernandez, Felix eHernandez, Jesus eAvila, Jesus eAvila   +5 more
doaj   +1 more source

Lack of an association between SNPs within the cholinergic receptor genes and smoking behavior in a Czech post-MONICA study [PDF]

Genetics and Molecular Biology, 2014
Smoking has a significant heritable component of approximately 30-60%. Recent genome wide association studies have identified single nucleotide polymorphisms (SNPs) within the nicotinic cholinergic receptor subunits 3 (rs578776), 5 (rs16969968) and β3 ...
Jaroslav A. Hubacek, Vera Lanska, Vera Adamkova   +2 more
doaj   +3 more sources

Non-neuronal regulation and repertoire of cholinergic receptors in organs

Biomolecular Concepts, 2010
Many studies on the cholinergic pathway have indicated that cholinergic receptors, which are widely expressed in various cells, play an important role in all body organs.
Sato Tsuyoshi, Chida Dai, Iwata Takanori, Usui Michihiko, Hatori Kouki, Abe Takahiro, Takeda Shu, Yoda Tetsuya   +7 more
doaj   +1 more source

Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections

mSphere, 2019
Acetylcholine modulates the virulence of Candida albicans and regulates an appropriate immune response to infection in a Galleria mellonella infection model. Indeed, the evidence suggests that C.
Christopher Nile, Monica Falleni, Daniela Cirasola, Abeer Alghamdi, Oliver F. Anderson, Christopher Delaney, Gordon Ramage, Emerenziana Ottaviano, Delfina Tosi, Gaetano Bulfamante, Giulia Morace, Elisa Borghi   +11 more
doaj   +1 more source