Results 231 to 240 of about 141,255 (305)

Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Neurotoxic protein accumulation is widely recognized as a key feature of Alzheimer's disease (AD), and increasing evidence indicates that impaired brain clearance associated with dysfunction of the meningeal lymphatic and glymphatic may contribute to this process.
Jiheng Zhang, Jiren Zhang, Jian Ding, Xian Zhang, Yuhua Wang, Wei Wei, Yan Chai, Shu Zhang, Xin Chen   +8 more
wiley   +1 more source

Acetylcholine demixes heterogeneous dopamine signals for learning and moving. [PDF]

Nat Neurosci
Jang HJ, McMahon Ward R, Golden CEM, Constantinople CM.   +3 more
europepmc   +1 more source

Analysis of Dendritic Specializations in Two Classes of Kenyon Cells in the Mushroom Body of the Adult Honeybee, Apis mellifera

Journal of Comparative Neurology, Volume 534, Issue 5, May 2026.
Honeybee mushroom bodies (MBs), sites for learning and memory, house two classes of intrinsic neurons: class I and II Kenyon cells (KCs) that form synaptic complexes with boutons of projection neurons (PNs) from primary sensory neuropils. Dendrites of both KC classes were restricted to distinct unimodal MB compartments.
Andrea Rafaela Nicolaidou, Basil el Jundi, Wolfgang Rössler, Claudia Groh   +3 more
wiley   +1 more source

Prevalence and Risk Factors of Dementia Among Older People of Gelao Ethnicity in China: A National Cross‐Sectional Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study reveals a 24.74% prevalence of dementia among elderly Gelao people in China, with women's rates more than double those of men and substantially exceeding the national average. We identify distinct sociocultural protective factors—including community engagement and traditional diets—alongside risk factors.
Xiaoling Zhao, Dan Meng, Xiaoli Yuan, Yong Luo, Jinghuan Gan, Mei He, Yuhong Long, Yan Zhang, Xia Wu, Bin Zhao, Pan Cai   +10 more
wiley   +1 more source

Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex. [PDF]

Cereb Cortex
Vattino LG, Clayton KK, Hackett TA, Polley DB, Takesian AE.   +4 more
europepmc   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He, Hanxiao Xue, Sheng Bi, Yan Wang, Xiaocao Liu, Yixia Li, Zhigeng Chen, Dongdong Rong, Bixiao Cui, Jie Ma, Shaozhen Yan, Jie Lu   +11 more
wiley   +1 more source

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

Multi‐Target‐Directed Ligands (MTDLs) as Potential Therapeutic Candidates Targeting Multiple Pathogenic Factor of Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Multi‐target‐directed ligands (MTDLs) offer a promising strategy for Alzheimer's disease by simultaneously modulating amyloid‐β, tau pathology, neuroinflammation, and oxidative stress. This review highlights representative MTDL candidates and their therapeutic potential in addressing the multifactorial nature of AD.
Jaewoon Jung, Yebeen Kim, Asifiwe Clarisse Cirunduzi, Seonghyun Yoon, Seokyoung Bang, Seung‐Hoon Yang   +5 more
wiley   +1 more source

Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department. [PDF]

Clin Case Rep
Tokioka K, Nojima T, Matsuo I, Tsukahara K, Nakao A.   +4 more
europepmc   +1 more source