ABSTRACT According to the functional ensemble of temperament (FET) model, individual differences in temperament arise from the balance of neurotransmitter systems also crucial for regulating circadian rhythms and sleep, suggesting a strong neurobiological link between temperament and sleep behavior.
Stefano Lasaponara +6 more
wiley +1 more source
The neuro-immune axis in cancer: mechanisms of neural regulation of immunity within the tumor microenvironment to promote cancer progression. [PDF]
Ran Z, Zeng C, Han J, Yu X.
europepmc +1 more source
Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism
ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental condition lacking effective pharmacological treatments. Metformin has emerged as a candidate for drug repurposing in ASD due to its metabolic and neurobiological actions. This study evaluated the in vivo effects of metformin (400 mg/kg, orally) administered from postnatal day 21 to
Madna Costa Freitas +9 more
wiley +1 more source
Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice. [PDF]
Rybicki-Kler CI +7 more
europepmc +1 more source
Therapeutic Potential of Oxiracetam in Neurocognitive Disorders: A Narrative Review. [PDF]
Ali H +4 more
europepmc +1 more source
Spatial Collinearity Constrains Multivariate Molecular‐Enriched Network Estimation
Spatial collinearity among PET maps undermines multivariate network estimation and obscures drug mechanisms. Moving from multivariate to univariate modelling resolves this instability, significantly boosting test–retest reliability and uncovering clear, receptor‐specific pharmacodynamics in pharmacoimaging data.
Timothy Lawn +4 more
wiley +1 more source
A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease. [PDF]
Jackson BL.
europepmc +1 more source
Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea
In a post hoc analysis of the Tie‐COPD trial, including 305 patients with mild‐to‐moderate COPD and no dyspnea (mMRC 0), 2 years of tiotropium improved lung function, lowered the annual exacerbation rate, and delayed the first clinically important deterioration, indicating benefit beyond symptom relief in a group not currently offered maintenance ...
Zihui Wang +15 more
wiley +1 more source
Dopamine and Acetylcholine in the Striatum: Circuit Interactions and Behavioral Control in Substance Use Disorders. [PDF]
Dinckol O +4 more
europepmc +1 more source
ABSTRACT Introduction/Aims Quantitative muscle ultrasound (QMUS) is a validated technique for assessing muscle pathology, yet its role in disorders primarily affecting the neuromuscular junction (NMJ) remains unclear. This pilot study aimed to explore whether QMUS is associated with structural muscle changes in patients with acquired or genetic NMJ ...
Artor Pogosean +3 more
wiley +1 more source

