Results 211 to 220 of about 653,806 (301)

Individual Differences in Sleep Quality: Exploring the Impact of Temperament on Sleep Through Anxiety and Depression

open access: yesPersonality and Mental Health, Volume 20, Issue 4, November 2026.
ABSTRACT According to the functional ensemble of temperament (FET) model, individual differences in temperament arise from the balance of neurotransmitter systems also crucial for regulating circadian rhythms and sleep, suggesting a strong neurobiological link between temperament and sleep behavior.
Stefano Lasaponara   +6 more
wiley   +1 more source

Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism

open access: yesDevelopmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental condition lacking effective pharmacological treatments. Metformin has emerged as a candidate for drug repurposing in ASD due to its metabolic and neurobiological actions. This study evaluated the in vivo effects of metformin (400 mg/kg, orally) administered from postnatal day 21 to
Madna Costa Freitas   +9 more
wiley   +1 more source

Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice. [PDF]

open access: yesAlzheimers Dement
Rybicki-Kler CI   +7 more
europepmc   +1 more source

Spatial Collinearity Constrains Multivariate Molecular‐Enriched Network Estimation

open access: yesHuman Brain Mapping, Volume 47, Issue 14, October 1, 2026.
Spatial collinearity among PET maps undermines multivariate network estimation and obscures drug mechanisms. Moving from multivariate to univariate modelling resolves this instability, significantly boosting test–retest reliability and uncovering clear, receptor‐specific pharmacodynamics in pharmacoimaging data.
Timothy Lawn   +4 more
wiley   +1 more source

Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea

open access: yesMedComm, Volume 7, Issue 10, October 2026.
In a post hoc analysis of the Tie‐COPD trial, including 305 patients with mild‐to‐moderate COPD and no dyspnea (mMRC 0), 2 years of tiotropium improved lung function, lowered the annual exacerbation rate, and delayed the first clinically important deterioration, indicating benefit beyond symptom relief in a group not currently offered maintenance ...
Zihui Wang   +15 more
wiley   +1 more source

Exploring the Value of Quantitative Muscle Ultrasound in Neuromuscular Junction Disorders: A Pilot Study

open access: yesMuscle &Nerve, Volume 74, Issue 4, Page 1281-1287, October 2026.
ABSTRACT Introduction/Aims Quantitative muscle ultrasound (QMUS) is a validated technique for assessing muscle pathology, yet its role in disorders primarily affecting the neuromuscular junction (NMJ) remains unclear. This pilot study aimed to explore whether QMUS is associated with structural muscle changes in patients with acquired or genetic NMJ ...
Artor Pogosean   +3 more
wiley   +1 more source

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