Results 171 to 180 of about 11,764 (203)

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

Blood, 1998
AbstractThe chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 (fusin, LESTR) are likely to be involved in the trafficking of hematopoietic progenitor and stem cells, as suggested by the reduced bone marrow hematopoiesis in SDF-1–deficient mice and the chemotactic effect of SDF-1 on CD34+ progenitor cells.
R, Möhle, F, Bautz, S, Rafii, M A, Moore, W, Brugger, L, Kanz   +5 more
openaire   +4 more sources

Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: Does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?

Joint Bone Spine, 2006
To analyze the CXCR-1 and CXCR-2 chemokine receptor expression on peripheral blood neutrophils (PBN) and synovial fluid neutrophils (SFN) of patients with rheumatoid arthritis (RA) and Behçet's disease (BD) (characterized by erosive and non-erosive arthritis, respectively), and to compare them with those of patients with osteoarthritis (OA).We used ...
Salih, Pay, Ugur, Musabak, Ismail, Simşek, Aysel, Pekel, Hakan, Erdem, Ayhan, Dinç, Ali, Sengül   +6 more
openaire   +2 more sources

C-X-C Chemokine Receptor Type 4 (CXCR-4) Functionally-Selective Allosteric Agonist ATI2341 Promotes the Recovery of Uterosacral Ligament

Journal of Biomaterials and Tissue Engineering, 2023
This study intends to assess whether CXCR4 functionally-selective allosteric agonist ATI2341 recovers uterosacral ligament. The 50 female rats were assigned into five groups including A group (normal healthy rats), B group (rats with uterine ligament injury), C group (injury rats treated with UC-MSCs cells), D group (treated with ATI2341); E group ...
Jing Zhang, Zhendong Zhang, Xiaofeng Wu
openaire   +2 more sources

The CXC chemokine receptors of fish: Insights into CXCR evolution in the vertebrates

General and Comparative Endocrinology, 2015
This article will review current knowledge on CXCR in fish, that represent three distinct vertebrate groups: Agnatha (jawless fishes), Chondrichthyes (cartilaginous fishes) and Osteichthyes (bony fishes). With the sequencing of many fish genomes, information on CXCR in these species in particular has expanded considerably. In mammals, 6 CXCRs have been
Jun, Zou, Anthony K, Redmond, Zhitao, Qi, Helen, Dooley, Chris J, Secombes   +4 more
openaire   +2 more sources

The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour

Journal of Oral Pathology & Medicine, 2014
BackgroundChemokines regulate physiological and pathological leucocyte trafficking, and chemokine receptors play a role in tumorigenesis. Expression of interleukin‐8 (IL‐8) receptors CXCR1 and CXCR2 has been shown in oral squamous cell carcinoma (OSCC) but remains poorly characterised.
Syed A, Khurram, Lynne, Bingle, Brenka M, McCabe, Paula M, Farthing, Simon A, Whawell   +4 more
openaire   +2 more sources

CXCR‐4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells

Journal of Surgical Oncology, 1998
Using the technique of differential hybridization of Atlas Human cDNA expression arrays, we previously reported the isolation of a G protein coupled receptor, CXCR-4, which is overexpressed in glioblastoma multiforme tumor tissue (GMTT) compared to normal brain tissue (NBT).Using gene specific reverse transcriptase-polymerase chain reaction (RT-PCR ...
A, Sehgal, C, Keener, A L, Boynton, J, Warrick, G P, Murphy   +4 more
openaire   +2 more sources

Dissociation of ligand-induced internalization of CXCR-4 from its co-receptor activity for HIV-1 Env-mediated membrane fusion

Archives of Virology, 1998
The C-terminal cytoplasmic tail of chemokine receptors is important for their internalization upon ligand binding. We generated several deletion mutants of the C-terminal cytoplasmic tail of CXCR-4, a co-receptor for T cell line tropic strains of human immunodeficiency virus type 1 (HIV-1), to know whether or not co-receptor internalization is ...
H, Hu, T, Shioda, T, Hori, C, Moriya, A, Kato, Y, Sakai, K, Matsushima, T, Uchiyama, Y, Nagai   +8 more
openaire   +2 more sources

CXCR4 and CXCR7 form a functional receptor unit for SDF‐1/CXCL12 in primary rodent microglia

Neuropathology and Applied Neurobiology, 2013
AimsMicroglial cells have been originally identified as a target for the CXC chemokine, SDF‐1, by their expression of CXCR4. More recently, it has been recognized that SDF‐1 additionally binds to CXCR7, which depending on the cell type acts as either a nonclassical, a classical or a scavenger chemokine receptor.
J, Lipfert, V, Ödemis, D-C, Wagner, J, Boltze, J, Engele   +4 more
openaire   +2 more sources

The specificity and molecular basis of alpha1-adrenoceptor and CXCR chemokine receptor dimerization.

Journal of molecular neuroscience : MN, 2005
It is now well established that rhodopsin-like, family-A G protein-coupled receptors (GPCRs) can exist within homo- and heterodimeric/oligomeric complexes. However, limited information is currently available on the molecular basis of these interactions or their selectivity.
Graeme, Milligan, Shirley, Wilson, Juan F, López-Gimenez   +2 more
openaire   +1 more source

Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR‐4‐dependent up‐regulation of urokinase‐type plasminogen activator receptor (uPAR, CD87) expression [PDF]

The Journal of Pathology, 2008
AbstractHere we show the increase of invasion of three breast cancer cell lines (8701‐BC, MDA‐MB‐231 and SKBR3) upon long‐term co‐incubation with culture medium of normal microvascular endothelial cells (MVEC) and normal breast epithelial cells (HB2).
SERRATI', SIMONA, MARGHERI, FRANCESCA, FIBBI, GABRIELLA, G. DI CARA, L. MINAFRA, I. PUCCI MINAFRA, LIOTTA, FRANCESCO, ANNUNZIATO, FRANCESCO, PUCCI, MARCO, DEL ROSSO, MARIO   +9 more
openaire   +4 more sources