Results 101 to 110 of about 80,643 (282)
Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System
International Journal of Endocrinology, 2014 Chemokines are chemotactic regulators of immune surveillance in physiological and pathological conditions such as inflammation, infection, and cancer.
Federica Barbieri +9 more
doaj +1 more source
The role of CXC receptors signaling in early stages of mouse embryonic stem cell differentiation
Stem Cell Research, 2019 Interplay between CXCR7 and other CXC receptors, namely CXCR4 or CXCR3, binding such ligands as SDF-1 or ITAC, was shown to regulate multiple cellular processes.
Kamil Kowalski +2 more
doaj +1 more source
Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis. [PDF]
J Biol Chem, 2023 Gill KS +5 more
europepmc +1 more source
Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]
, 2013 Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A. +6 more
core +2 more sources
Advanced Science, EarlyView.ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs +4 more
wiley +1 more source
The complex nature of CXCR4 mutations in WHIM syndrome
Frontiers in ImmunologyHeterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal region of the CXCR4 chemokine receptor, specifically several potential ...
José Miguel Rodríguez-Frade +4 more
doaj +1 more source
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
Nature Communications, 2016 G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139 ...
Irinna Papangeli +13 more
doaj +1 more source
Colorectal Cancer: The Contribution of CXCL12 and Its Receptors CXCR4 and CXCR7. [PDF]
Cancers (Basel), 2022 Goïta AA, Guenot D.
europepmc +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
Journal of Translational Medicine, 2012 Background Previously assumed to be a select ligand for chemokine receptor CXCR4, chemokine CXCL12 is now known to activate both CXCR4 and CXCR7. However, very little is known about the co-expression of these receptors in cancer cells.
Heinrich Eileen L +4 more
doaj +1 more source