Results 121 to 130 of about 49,164 (249)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng +3 more
wiley +1 more source
Transcriptional and translational-uncoupling in regulation of the CXCL12 and its receptors CXCR4, 7 in THP-1 monocytes and macrophages. [PDF]
Immun Inflamm Dis, 2018 Yu L, Yu L, Pham Q, Wang TTY.
europepmc +1 more source
Allergy, EarlyView.Upregulated HLA‐B*57:01 expression in Tg/KO mice amplifies abacavir‐specific CD8+ T‐cell activation, driven by enhanced antigen presentation. Abacavir treatment induces robust pDC expansion and IFN‐α production, which selectively suppresses memory Treg populations.
SuJin Hwang +8 more
wiley +1 more source
Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Diagnosis and management of neutropenia in adults: Expert guidance
British Journal of Haematology, EarlyView.Severe neutropenia can result from decreased production of neutrophil precursors in the bone marrow, as in the case of severe congenital neutropenia, or from increased utilization of neutrophils or their accelerated destruction as for drug‐induced neutropenia or autoimmune neutropenia. Severe chronic neutropenia increases susceptibility to bacterial or
Karl Welte +5 more
wiley +1 more source
Iranian Journal of Public Health, 2015 Background: Chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. In this study, the gene expression profile of some key chemokine receptors involved in metastasis has been ...
Mohammad Amir MISHAN +6 more
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Brain Pathology, EarlyView.Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira +19 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements. [PDF]
PLoS One, 2017 Doijen J +6 more
europepmc +1 more source