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The chemokine receptors CXCR4 and CXCR3 in cancer
Current Oncology Reports, 2009Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to sites of inflammation or injury. In addition to mediating cellular migration, chemokine/chemokine receptor pairs have been shown to affect many ...
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Expression of chemokine receptor CXCR4 during chick embryo development
Anatomy and Embryology, 2005The chemokine receptor CXCR4 plays a decisive role in physiological cell migration both in developmental processes and adult tissues; it has also been implicated in metastasis formation of different human cancers (Balkwill 2004) and in HIV pathogenesis (Murdoch 2000).
Yusuf, Faisal +3 more
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CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4
Journal of Molecular Medicine, 2014Chemokines were recognized originally for their ability to dictate the migration and activation of leukocytes. However, CXC chemokine ligand 12 (CXCL12, also known as stromal cell-derived factor-1) and its receptor CXCR4 are the first chemokine and receptor that have been shown to be critical for developmental processes, including homing and ...
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[Multiple talents of the chemokine receptor-CXCR4].
Medecine sciences : M/S, 2008CXCR4 is a clinically relevant chemokine receptor that has first gained attention as one of the cofactors for HIV entry into target cells. Moreover, the receptor is involved in cancer cell migration to distant metastatic sites and immune effector recruitment in inflammatory diseases such as asthma and rheumatoid arthritis.
Sonia F, Desjardins +3 more
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Eosinophils Through the CXCR4 Chemokine Receptor
Journal of Allergy and Clinical Immunology, 2013Christof Straub +2 more
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