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CXCR4 chemokine receptor antagonists: perspectives in SCLC
Expert Opinion on Investigational Drugs, 2009Small-cell lung cancer (SCLC) is a particularly aggressive form of lung cancer characterized by early and widespread metastases and the ability to rapidly develop resistance against chemotherapeutic agents. Tumor cell migration and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokine receptors and ...
Jan A, Burger, David J, Stewart
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The chemokine receptors CXCR4 and CXCR3 in cancer
Current Oncology Reports, 2009Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to sites of inflammation or injury. In addition to mediating cellular migration, chemokine/chemokine receptor pairs have been shown to affect many ...
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The good and bad faces of the CXCR4 chemokine receptor
The International Journal of Biochemistry & Cell Biology, 2018Chemokines are chemotactic cytokines that promote cell migration and activation under homeostatic and inflammatory conditions. Chemokines bind to seven transmembrane-spanning receptors that are coupled to heterotrimeric guanine nucleotide-binding (G) proteins, which are the responsible for intracellularly transmitting the activating signals for cell ...
Joaquin, Teixidó +3 more
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Importance of Receptor Flexibility in Binding of Cyclam Compounds to the Chemokine Receptor CXCR4
Journal of Chemical Information and Modeling, 2010We have elucidated the binding sites of four moncyclam and one bicyclam antagonist AMD3100, in the human chemokine receptor CXCR4. Using the predicted structural models of CXCR4, we have further predicted the binding sites of these cyclam compounds. We used the computational method LITiCon to map the differences in receptor structure stabilized by the ...
Alfonso Lam +5 more
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Expression of CXCR4 Receptors in Refractory Atypical Mediastinal Carcinoid
Clinical Nuclear Medicine, 2020Abstract Primary neuroendocrine tumor of the mediastinum is a relatively rare entity. In metastatic/inoperable disease, therapeutic options are limited to cytotoxic chemotherapy in poorly differentiated tumors and peptide receptor radionuclide therapy in case of well-differentiated tumors.
Venkata Subramanian, Krishnaraju +6 more
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A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
Nature, 2002Germ cells preserve an individual's genetic information and transmit it to the next generation. Early in development germ cells are set aside and undergo a specialized developmental programme, a hallmark of which is the migration from their site of origin to the future gonad.
Knaut, H. +4 more
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[Multiple talents of the chemokine receptor-CXCR4].
Medecine sciences : M/S, 2008CXCR4 is a clinically relevant chemokine receptor that has first gained attention as one of the cofactors for HIV entry into target cells. Moreover, the receptor is involved in cancer cell migration to distant metastatic sites and immune effector recruitment in inflammatory diseases such as asthma and rheumatoid arthritis.
Sonia F, Desjardins +3 more
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CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis
Ageing Research Reviews, 2023Yang Yang, Wangrui Lei, Ran Tang
exaly