Results 241 to 250 of about 80,643 (282)

The interrelationship between prostate cancer and osteoporosis: new perspectives on shared molecular pathways and treatment strategies. [PDF]

Int J Surg
Jiang Z, Zhang J, Qiu Z, Li Z, Zhang L, Zhu Z.   +5 more
europepmc   +1 more source

Fucoidan: An Update on Function, Role in Human Health and Applications

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
Fucoidan is a promising bioactive compound with anti‐inflammatory, anticoagulant, anticancer, antioxidant, antiviral, and cardioprotective properties. In addition, thanks to its epigenetic potential, ability to modulate autophagic mechanisms and possibility adjuvant agent or bioactive component of the drug delivery systems, fucoidan is a promising ...
Sharon Critelli, Marilena Celano
wiley   +1 more source

Cholesterol oxidase treatment impairs CXCR4-mediated T cell migration. [PDF]

Cell Commun Signal
Gardeta SR, García-Cuesta EM, Palacios BS, Bueno RA, Quijada-Freire A, Acerete NS, Rodríguez-Frade JM, Mellado M.   +7 more
europepmc   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases. [PDF]

Arthritis Res Ther
Ruths L, de Hesselle H, Haußner F, Albers S, Harms M, Freitag T, Münch J, Riegger J.   +7 more
europepmc   +1 more source

B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) is increasingly recognized not just as a lipid‐driven disease, but as a complex interplay between vascular cells and the immune system. Accumulating evidence highlights a central, yet heterogeneous role for B cells in atherogenesis, with distinct subsets displaying opposing roles.
Sophieke Lems, Megan Grace Mazzei, Amanda C. Foks, Coleen A. McNamara   +3 more
wiley   +1 more source

The Mechanism of G Protein-Coupled Receptor Regulation of Ferroptosis in Hepatic Ischemia-Reperfusion Injury. [PDF]

Int J Mol Sci
Hu D, Sun L, Su M, Xing X.
europepmc   +1 more source

Peptide Angio‐3 Attenuates Pulmonary Fibrosis Via Modulation of the Coagulation Factor Xa—Protease‐Activated Receptor‐1 Signaling Axis

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Schematic illustrating the mechanism by which the peptide Angio‐3 attenuates pulmonary fibrosis. Following lung injury, activation of the coagulation cascade via Factor Xa (FXa) signals through protease‐activated receptor‐1 (PAR‐1) to activate fibroblasts and promote fibrosis.
Dan Wang, Fei Li, Hui Chen, Bochuan Deng, Lu Cheng, Jiawen Ma, Rong Li, Lang Qu, Junqiu Xie, Ya Zhao   +9 more
wiley   +1 more source

Chemokines in the resolution of inflammation: key players and targets for therapeutic modulation. [PDF]

Front Immunol
Oliveira VLS, Proost P, Struyf S.
europepmc   +1 more source

CXCR4-modification enhances CAR-T efficacy by improving tumor tracking and bone marrow homing in B-cell malignancies. [PDF]

Signal Transduct Target Ther
Shu P, Guo F, Qin D, Zou L, Ma Q, Zhang B, Gao G, Chen Y, He X, Jiang M, Liu N, Zhou K, Zhao J, Lei Y, Gao Y, Zhang Y, Zeng Y, Feng M, Li X, Li D, Wang Y.   +20 more
europepmc   +1 more source