Results 241 to 250 of about 599,394 (294)

Mapping the CXCR4 receptor on breast cancer cells

Biomaterials, 2015
The CXCR4 receptor triggers cell migration and, in breast cancer, promotes metastasis. To date, the dynamic assembly of CXCR4 on the cell surface as a mediator of receptor binding is not well characterized. The objective of this work is to quantify the density, spatial organization, and magnitude of binding of the CXCR4 receptor on live metastatic ...
Biran Wang, Debra Auguste
exaly   +3 more sources

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source

CXCR4: chemokine receptor extraordinaire

Immunological Reviews, 2000
Current investigations show that chemokine receptor CXCR4 is functionally expressed on a multitude of tissues and cell types, including different leukocyte subsets, hematopoietic progenitor cells and non-hematopoietic cells such as endothelial and epithelial cells.
openaire   +2 more sources

CXCR4 Receptor as a Promising Target for Oncolytic Drugs

Mini-Reviews in Medicinal Chemistry, 2008
There has been considerable in vivo evidence that chemokine receptor CXCR4 and its endogenous ligand CXCL12 modulate some important physiological and pathophysiological processes, including cancer metastasis, angiogenesis, invasion, growth and progression. In this review we elucidate key aspects of CXCL12-CXCR4 signaling system with emphasis on peptide-
Yan, Lavrovsky, Yan A, Ivanenkov, Konstantin V, Balakin, Darya A, Medvedeva, Alexandre V, Ivachtchenko   +4 more
openaire   +2 more sources

Chemokine receptor CXCR4: Role in gastrointestinal cancer

Critical Reviews in Oncology/Hematology, 2013
Chemokines (CK)s, small proinflammatory chemoattractant cytokines that bind to specific G-protein coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184).
Lombardi L., Tavano F., Morelli F., Latiano T. P., Di Sebastiano P., Maiello E.   +5 more
openaire   +2 more sources

Imaging agents for the chemokine receptor 4 (CXCR4)

Chemical Society Reviews, 2012
The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body. However, CXCR4 over-expression is also found in diseases such as cancer, where it plays a role in, among others, the metastatic spread. For this reason it is an interesting biomarker
Kuil, J., Buckle, T., Leeuwen, F.W.B. van   +2 more
openaire   +3 more sources

Configurationally Restricted Bismacrocyclic CXCR4 Receptor Antagonists

Journal of Medicinal Chemistry, 2006
A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with ...
Gina C, Valks, Graeme, McRobbie, Elizabeth A, Lewis, Timothy J, Hubin, Tina M, Hunter, Peter J, Sadler, Christophe, Pannecouque, Erik, De Clercq, Stephen J, Archibald   +8 more
openaire   +2 more sources