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Expression of CXCR4 Receptors in Refractory Atypical Mediastinal Carcinoid
Clinical Nuclear Medicine, 2020Abstract Primary neuroendocrine tumor of the mediastinum is a relatively rare entity. In metastatic/inoperable disease, therapeutic options are limited to cytotoxic chemotherapy in poorly differentiated tumors and peptide receptor radionuclide therapy in case of well-differentiated tumors.
Venkata Subramanian, Krishnaraju +6 more
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CXCR4-Receptor-Targeted Liposomes for the Treatment of Peritoneal Fibrosis
Molecular Pharmaceutics, 2019Peritoneal fibrosis (PF) is a common complication of long-term peritoneal dialysis (PD). It is considered as the main reason for dialysis inadequacy and PD withdrawal. Transforming growth factor beta (TGF-β) regulates the expression of stromal cell-derived factor 1 (SDF-1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) on human peritoneal ...
Khan Asifullah +7 more
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Soluble chemokine receptor CXCR4 is present in human sera
Analytical Biochemistry, 2011A soluble form of the chemokine receptor CXCR4 was detected in human sera by isoelectric focusing and Western blotting. Sera of patients and normal subjects were analyzed using a panel of specific antibodies. Compared with controls, high levels of serum CXCR4 were found in patients with inflammatory bowel diseases. Serum CXCR4 levels in the majority of
Etienne, Malvoisin +3 more
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Structure-Based Development of Antagonists for Chemokine Receptor CXCR4
Current Computer Aided-Drug Design, 2013The C-X-C chemokine receptor-4(CXCR4) is a G-protein coupled receptor (GPCR) which belongs to the family I GPCR or rhodopin-like GPCR family. CXCR4 plays a crucial role as a co-receptor with CCR5 for HIV-1 anchoring to mammalian cell membrane, and is implicated in cancer metastasis and inflammation.
Chongqian, Zhang +3 more
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[Multiple talents of the chemokine receptor-CXCR4].
Medecine sciences : M/S, 2008CXCR4 is a clinically relevant chemokine receptor that has first gained attention as one of the cofactors for HIV entry into target cells. Moreover, the receptor is involved in cancer cell migration to distant metastatic sites and immune effector recruitment in inflammatory diseases such as asthma and rheumatoid arthritis.
Sonia F, Desjardins +3 more
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Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity
Circulation, 2017Yvonne Döring +2 more
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