Results 211 to 220 of about 49,164 (249)
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Imaging agents for the chemokine receptor 4 (CXCR4)
Chemical Society Reviews, 2012The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body. However, CXCR4 over-expression is also found in diseases such as cancer, where it plays a role in, among others, the metastatic spread. For this reason it is an interesting biomarker
Kuil, J. +2 more
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Chemokine receptor CXCR4: Role in gastrointestinal cancer
Critical Reviews in Oncology/Hematology, 2013Chemokines (CK)s, small proinflammatory chemoattractant cytokines that bind to specific G-protein coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184).
Lombardi L. +5 more
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The significance of cancer cell expression of the chemokine receptor CXCR4
Seminars in Cancer Biology, 2004Malignant cells from at least 23 different types of cancer express the chemokine receptor CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved in directed migration of cancer cells to sites of metastasis, increased survival of cancer cells in sub optimal conditions and establishment of a tumour promoting cytokine ...
Fran Balkwill
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CXCR4 chemokine receptor antagonists: perspectives in SCLC
Expert Opinion on Investigational Drugs, 2009Small-cell lung cancer (SCLC) is a particularly aggressive form of lung cancer characterized by early and widespread metastases and the ability to rapidly develop resistance against chemotherapeutic agents. Tumor cell migration and metastasis share many similarities with leukocyte trafficking, which is critically regulated by chemokine receptors and ...
Jan A, Burger, David J, Stewart
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The good and bad faces of the CXCR4 chemokine receptor
The International Journal of Biochemistry & Cell Biology, 2018Chemokines are chemotactic cytokines that promote cell migration and activation under homeostatic and inflammatory conditions. Chemokines bind to seven transmembrane-spanning receptors that are coupled to heterotrimeric guanine nucleotide-binding (G) proteins, which are the responsible for intracellularly transmitting the activating signals for cell ...
Joaquin, Teixidó +3 more
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Importance of Receptor Flexibility in Binding of Cyclam Compounds to the Chemokine Receptor CXCR4
Journal of Chemical Information and Modeling, 2010We have elucidated the binding sites of four moncyclam and one bicyclam antagonist AMD3100, in the human chemokine receptor CXCR4. Using the predicted structural models of CXCR4, we have further predicted the binding sites of these cyclam compounds. We used the computational method LITiCon to map the differences in receptor structure stabilized by the ...
Alfonso Lam +5 more
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The chemokine receptors CXCR4 and CXCR3 in cancer
Current Oncology Reports, 2009Chemokines comprise a superfamily of at least 46 cytokines that were initially described based on their ability to bind to 18 to 22 G protein-coupled receptors to induce the directed migration of leukocytes to sites of inflammation or injury. In addition to mediating cellular migration, chemokine/chemokine receptor pairs have been shown to affect many ...
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A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
Nature, 2002Germ cells preserve an individual's genetic information and transmit it to the next generation. Early in development germ cells are set aside and undergo a specialized developmental programme, a hallmark of which is the migration from their site of origin to the future gonad.
Holger, Knaut +3 more
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The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Mini-Reviews in Medicinal Chemistry, 2006CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12-CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA).
Hirokazu Tamamura +2 more
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CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes
Journal of Neurovirology, 2001Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1alpha (SDF-1alpha), SDF-1beta, or the bicyclam AMD3100 in a dose-dependent manner ...
K, Nakagaki +5 more
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