Results 201 to 210 of about 49,164 (249)

Radiopharmaceutical Theranostics in Primary Adrenal Malignancies: A Surgeon's Perspective. [PDF]

Pharmaceuticals (Basel)
Laskou S, Geropoulos G, Radu PA, Pirvu C, Surlin V, Kosmidis C, Psarras K, Pantea S, Strambu V, Sapalidis K.   +9 more
europepmc   +1 more source

Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PDF]

Curr Atheroscler Rep
Zangas P, Georgakis MK.
europepmc   +1 more source

Theranostic applications of CXCR4-targeted imaging ligands in lymphoma: integrating diagnosis and precision therapy. [PDF]

Am J Nucl Med Mol Imaging
Dhamecha KR, Booth OC, Oderinde OM, Zheng QH.   +3 more
europepmc   +1 more source

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Mapping the CXCR4 receptor on breast cancer cells

Biomaterials, 2015
The CXCR4 receptor triggers cell migration and, in breast cancer, promotes metastasis. To date, the dynamic assembly of CXCR4 on the cell surface as a mediator of receptor binding is not well characterized. The objective of this work is to quantify the density, spatial organization, and magnitude of binding of the CXCR4 receptor on live metastatic ...
Biran Wang, Debra T Auguste
exaly   +3 more sources

Cbl Regulates CXCR4-Mediated Chemotaxis and CXCR4 Receptor Internalization.

Blood, 2004
Abstract CXCL12-induced and CXCR4-mediated chemotaxis plays a critical role in the trafficking of lymphocytes, which modulates inflammatory and immune responses. The CXCR4 receptor is down-modulated by its ligand CXCL12, which has been shown to inhibit HIV entry into the cells.
Ramesh K. Ganju, Aaron Z. Fernandis, Appakkudal R. Anand, Heather C. Lane   +3 more
openaire   +1 more source

CXCR4 Receptor as a Promising Target for Oncolytic Drugs

Mini-Reviews in Medicinal Chemistry, 2008
There has been considerable in vivo evidence that chemokine receptor CXCR4 and its endogenous ligand CXCL12 modulate some important physiological and pathophysiological processes, including cancer metastasis, angiogenesis, invasion, growth and progression. In this review we elucidate key aspects of CXCL12-CXCR4 signaling system with emphasis on peptide-
Yan, Lavrovsky, Yan A, Ivanenkov, Konstantin V, Balakin, Darya A, Medvedeva, Alexandre V, Ivachtchenko   +4 more
openaire   +2 more sources

CXCR4: chemokine receptor extraordinaire

Immunological Reviews, 2000
Current investigations show that chemokine receptor CXCR4 is functionally expressed on a multitude of tissues and cell types, including different leukocyte subsets, hematopoietic progenitor cells and non-hematopoietic cells such as endothelial and epithelial cells.
openaire   +2 more sources

Configurationally Restricted Bismacrocyclic CXCR4 Receptor Antagonists

Journal of Medicinal Chemistry, 2006
A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with ...
Gina C, Valks, Graeme, McRobbie, Elizabeth A, Lewis, Timothy J, Hubin, Tina M, Hunter, Peter J, Sadler, Christophe, Pannecouque, Erik, De Clercq, Stephen J, Archibald   +8 more
openaire   +2 more sources