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Are estrogen receptors cytoplasmic or nuclear? Some immunocytochemical and biochemical studies.
Journal of Steroid Biochemistry, 1987The subcellular localization of estradiol receptor (ER) has been examined using various experimental approaches. Immunocytochemical studies using the monoclonal antibody JS 34/32, raised against calf uterine cytosolic ER, yielded only equivocal results. In general, cells and tissues pretreated with estradiol showed positive immunostaining in the nuclei
Indu Parikh +4 more
semanticscholar +3 more sources
Cytoplasmic and nuclear cytokine receptor complexes.
Vitamins and hormones, 1999Much of our understanding on how hormones and cytokines transmit their message into the cell is based on the receptor activation at the plasma membrane. Many experimental in vitro models have established the paradigm for cytokine action based upon such activation of their cell surface receptor.
H. Mertani, G. Morel, P. Lobie
semanticscholar +3 more sources
American Journal of Physiology, 1978 Binding of aldosterone to cytoplasmic and nuclear sites in urinary bladder epithelia of Bufo marinus (Dominican variant) is saturable and dependent upon steroid concentration.
M. Kusch, N. Farman, I. Edelman
semanticscholar +2 more sources
Cytoplasmic-nuclear trafficking of steroid hormone receptors.
Trends in Endocrinology & Metabolism, 1993The nuclear localization of most steroid hormone receptors reflects a dynamic process: the receptor constantly diffuses out of the nucleus and is reimported by an active mechanism. The outward movement from the nucleus of the receptors and of other nuclear proteins is also mediated by the nuclear localization signals.
A. Guiochon‐Mantel, E. Milgrom
semanticscholar +3 more sources
Nuclear and cytoplasmic receptors for 1,25-dihydroxycholecalciferol in intestinal mucosa.
Biochemical and Biophysical Research Communications, 1973The apparent hormonal form of cholecalciferol, 1,25-dihydroxycholecalciferol (1,25-(OH)2-CC), was incubated with intestinal mucosa homogenates and whole intestinal tissue, in vitro. After 40–70 min, 1,25-(OH)2-CC was specifically associated with the nuclear chromatin fraction.
Peter F. Brumbaugh, M. Haussler
semanticscholar +3 more sources
Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization
Biochemical and Biophysical Research Communications, 2021The glucocorticoid receptor (GR) plays an important role in steroid-dependent regulation of metabolism, development, and the immune response in humans. Although GR is known to be activated by the binding of glucocorticoid, the mechanism of action is poorly understood. We investigated dimerization of GR in the cytoplasm and nuclear trans-localization in
Su-Jun Lee +2 more
openaire +2 more sources
Nuclear and cytoplasmic estrogen receptors and progesterone receptors in breast cancer
European Journal of Cancer (1965), 1980The relationships of cytoplasmic estrogen receptors occupied and free nuclear estrogen receptors and cytoplasmic progesterone receptors measured in a series of 83 primary breast carcinoma were examined. 83% of the patients were postmenopausal (range in age 30-86 years; average age 59.7). Preparation of the cytosol and nuclear fractions were described
R, Hähnel +4 more
openaire +2 more sources
Molecular pathways involved in the transport of nuclear receptors from the nucleus to cytoplasm.
The Journal of Steroid Biochemistry and Molecular Biology, 2017Nuclear receptors (NRs) are transcription regulators that direct the expression of many genes linked to cellular processes, such as proliferation, differentiation, and apoptosis. Additionally, some cellular events are also modulated by signaling pathways induced by NRs outside of the nucleus.
Angeles C. Tecalco-Cruz
semanticscholar +3 more sources
Binding of aldosterone to cytoplasmic and nuclear receptors of the rabbit kidney
American Journal of Physiology-Cell Physiology, 1981The binding characteristics of [3H]aldosterone ([3H]A) in the rabbit kidney were compared with those described in other species, and experimental conditions suitable for both the isolation of renal tubules and the retention of aldosterone receptors were examined.
N, Farman, A, Vandewalle, J P, Bonvalet
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Biochemical and Biophysical Research Communications - BBRC, 2020
Desensitization of G protein-coupled receptors (GPCRs) represents a gradual attenuation of receptor responsiveness by continuous or repeated exposure to agonists.
M. Zheng +4 more
semanticscholar +1 more source
Desensitization of G protein-coupled receptors (GPCRs) represents a gradual attenuation of receptor responsiveness by continuous or repeated exposure to agonists.
M. Zheng +4 more
semanticscholar +1 more source