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Androgen Directs Apparent Cytoplasmic and Nuclear Distribution of Rat Cardiovascular Androgen Receptors [PDF]
We used either the synthetic androgen R1881 (methyltrienolone) or 5 alpha-dihydrotestosterone (5 alpha-DHT) to characterize androgen receptors in rat aortic and myocardial cytoplasmic and nuclear preparations. Relative steroid specificity studies established that only androgens were effective inhibitors of R1881 (cytoplasmic) or 5 alpha-DHT (nuclear ...
A. L. Lin, R. González, S. Shain
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Nuclear and cytoplasmic estrogen receptors and progesterone receptors in breast cancer
European Journal of Cancer (1965), 1980The relationships of cytoplasmic estrogen receptors occupied and free nuclear estrogen receptors and cytoplasmic progesterone receptors measured in a series of 83 primary breast carcinoma were examined. 83% of the patients were postmenopausal (range in age 30-86 years; average age 59.7). Preparation of the cytosol and nuclear fractions were described
R, Hähnel +4 more
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Ecdysteroid Receptors: A Comparison of Cytoplasmic and Nuclear Receptors from Crayfish Hypodermis
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1982Cytoplasmic and nuclear ecdysteroid receptors from intermolt Orconectes limosus integument have been compared. The specificities as well as the KD values for three [3H]ecdysteroids are very similar in both preparations. Using a photoaffinity labelling technique, the molecular mass of the hormone-receptor complexes from both preparations was determined ...
M, Londershausen +2 more
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Journal of Neurochemistry, 1981
Abstract: The affinity of a series of catecholestrogens for 7S cytoplasmic receptor proteins from hypothalamus and pituitary gland of ovariectomised rats was assessed in vitro by a competitive charcoal binding assay at 4°C. The equilibrium dissociation constants (Ki) of catecholestrogens 4‐hydroxyestradiol, 4‐hydroxyethynylestradiol, 2 ...
J. Kirchhoff +4 more
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Abstract: The affinity of a series of catecholestrogens for 7S cytoplasmic receptor proteins from hypothalamus and pituitary gland of ovariectomised rats was assessed in vitro by a competitive charcoal binding assay at 4°C. The equilibrium dissociation constants (Ki) of catecholestrogens 4‐hydroxyestradiol, 4‐hydroxyethynylestradiol, 2 ...
J. Kirchhoff +4 more
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Nuclear and cytoplasmic lectin receptor sites in rat Py1a osteoblasts.
Histology and histopathology, 2000The intracellular distribution of lectin receptor sites was studied in the rat Pyla osteoblasts using immunofluorescence at the confocal microscopy level. This immortalized cell line was found to represent a satisfactory model to study the occurrence and distribution of sugar moieties.
SABBIETI, Maria Giovanna +3 more
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Cytoplasmic and Nuclear Cytokine Receptor Complexes
1997Much of our understanding on how hormones and cytokines transmit their message into the cell is based on the receptor activation at the plasma membrane. Many experimental in vitro models have established the paradigm for cytokine action based upon such activation of their cell surface receptor.
H C, Mertani, G, Morel, P E, Lobie
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Cytoplasmic and nuclear signaling pathways of V1-vascular vasopressin receptors
Regulatory Peptides, 1993We studied the cytoplasmic and nuclear signaling pathways of V1-vascular AVP receptors of human platelets, primary cultures of renal glomerular mesangial cells, and established cultures of the A7r5 aortic smooth muscle cell line. The immediate transmembrane signals are triggered by the formation of ligand-receptor complexes as illustrated by binding ...
M, Thibonnier, A L, Bayer, Z, Leng
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Characteristics of Cytoplasmic and Nuclear Receptor Forms
1979Although this monograph is primarily concerned with the relationship between hormone-induced responses and nuclear binding, it is necessary to relate nuclear receptors to their cytoplasmic counterparts.
James H. Clark, Ernest J. Peck
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Characteristics of the cytoplasmic and nuclear dihydrotestosterone receptors of human thymic tissue
Steroids, 1983Dihydrotestosterone receptor was prepared from both the cytoplasm and nucleus of human thymic tissue. Human cytoplasmic and nuclear dihydrotestosterone receptor possessed a KA greater than 1.0 and by competition assay was highly specific for dihydrotestosterone.
C J, Grossman +2 more
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Nuclear‐cytoplasmic transport of EGFR involves receptor endocytosis, importin β1 and CRM1
Journal of Cellular Biochemistry, 2006AbstractMany receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR, HER‐2, HER‐3, HER‐4, and fibroblast growth factor receptor. EGFR, HER‐2 and HER‐4 contain transactivational activity and function as transcription co‐factors to activate gene promoters. High EGFR in tumor nuclei correlates with increased tumor proliferation
Hui-Wen, Lo +5 more
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