Results 101 to 110 of about 4,743,951 (299)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mutational and computational characterization of transmembrane domains in the fungal G protein-coupled pheromone receptors STE2 and Mam2 [PDF]

G protein-coupled receptors (GPCRs) comprise the largest family of cell-surface receptors involved in sensing a multitude of ligands and are consequently attractive pharmacological targets.
Nilsson Lock, Gun Antonia Evelina
core  

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite [PDF]

, 2011
Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors.
Wiegertjes Geert F., Geert Raes, Schijns Virgil E. J. C., Ghassabeh, G.H., Ghassabeh, Gholamreza H., Huub F. J. Savelkoul, Savelkoul, H.F.J., Geert F Wiegertjes, Savelkoul Huub F. J., Virgil E J C Schijns, Ghassabeh Gholamreza H., Gholamreza H. Ghassabeh, Maria J. S. L. Pontes, Ribeiro, Carla M. S., Wiegertjes, G.F., Raes, Geert, Savelkoul, Huub F. J., Carla M S Ribeiro, Schijns, V.E.J.C., Steve Bird, Raes, G., Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Schijns, Virgil E. J. C., Virgil E. J. C. Schijns, Raes Geert, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Gholamreza H Ghassabeh, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +2 more sources

The IRAK-M death domain: a tale of three surfaces

Frontiers in Molecular Biosciences
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent ...
Berke Gürkan, Berke Gürkan, Hessel Poelman, Hessel Poelman, Liza Pereverzeva, Liza Pereverzeva, Danielle Kruijswijk, Danielle Kruijswijk, Alex F. de Vos, Alex F. de Vos, Anouk G. Groenen, Anouk G. Groenen, Edgar E. Nollet, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Tom van der Poll, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, W. Joost Wiersinga, W. Joost Wiersinga, Gerry A. F. Nicolaes, Gerry A. F. Nicolaes, Cornelis van ‘t Veer, Cornelis van ‘t Veer   +26 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]

, 2007
Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D., Groot-Kormelink, P., Plested, A.J.R., Sivilotti, L.G.   +3 more
core  

Protein engineering expands the effector recognition profile of a rice NLR immune receptor

eLife, 2019
Plant nucleotide binding, leucine-rich repeat (NLR) receptors detect pathogen effectors and initiate an immune response. Since their discovery, NLRs have been the focus of protein engineering to improve disease resistance.
Juan Carlos De la Concepcion, Marina Franceschetti, Dan MacLean, Ryohei Terauchi, Sophien Kamoun, Mark J Banfield   +5 more
doaj   +1 more source

Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]

Adv Sci (Weinh)
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

BMC Neuroscience, 2004
Background Lithium, a mood stabilizer widely used to treat bipolar disorder, also is a neuroprotectant, providing neurons protection from apoptosis induced by a broad spectrum of toxic conditions.
Jope Richard S, Zhou Tong, Song Ling
doaj   +1 more source