Results 241 to 250 of about 4,743,951 (299)

The role of NLRP3 inflammasome in age-related macular degeneration: mechanisms and therapeutic prospects. [PDF]

Front Aging Neurosci
Zhu M, Yu W.
europepmc   +1 more source

PANoptosis and Immune Remodeling in the Tumor Microenvironment. [PDF]

FASEB J
Liu F, Zhou X, Liu Z, Luo J, Tao Q.
europepmc   +1 more source

A review on toxicities of T-cell engager-based therapies in solid tumors. [PDF]

Ther Adv Med Oncol
Bastien E, Vacheret C, Sanchez R, Lucibello F, Girard N, Romano E.   +5 more
europepmc   +1 more source

E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities. [PDF]

Liver Int
Oh AR, Jeong Y, Jung YH, Kim YU, Gi H, Kim DW, Choi YD, Lee SB, Kim K.   +8 more
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Structural and functional investigation of the cytoplasmic domain of the Fas death receptor

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Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors

Biochemical and Biophysical Research Communications, 2005
Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Hyun-Wook, Lee, Seung-Hyun, Lee, Hae-Won, Lee, Yeon-Woo, Ryu, Myung-Hee, Kwon, Yong-Sung, Kim   +5 more
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Apoptotic and necrotic cell death induced by death domain receptors

Cellular and Molecular Life Sciences, 2001
Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as initiators and effectors of apoptotic cell death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the ...
G, Denecker, D, Vercammen, W, Declercq, P, Vandenabeele   +3 more
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A death-domain-containing receptor that mediates apoptosis

Nature, 1996
The cell-killing effects of the cytokines TNF-alpha and FasL are mediated by the distinct cell-surface receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members of a receptor superfamily that is important for regulating cell survival.
J, Kitson, T, Raven, Y P, Jiang, D V, Goeddel, K M, Giles, K T, Pun, C J, Grinham, R, Brown, S N, Farrow   +8 more
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An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

Science, 1997
TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain–containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant ...
G, Pan, J, Ni, Y F, Wei, G, Yu, R, Gentz, V M, Dixit   +5 more
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Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, 2013
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) family of death receptors, including TNFR1 and TNFR2, and FAS and TNF-related apoptosis-inducing ligand (TRAIL) receptors.
Shan, Li, Li, Zhang, Qing, Yao, Lin, Li, Na, Dong, Jie, Rong, Wenqing, Gao, Xiaojun, Ding, Liming, Sun, Xing, Chen, She, Chen, Feng, Shao   +11 more
openaire   +2 more sources