Results 231 to 240 of about 287,209 (264)

Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub

Biological Reviews, 2019
ABSTRACTThe death domain (DD) is a globular protein motif with a signature feature of an all‐helical Greek‐key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma, and cancers.
Zhi Lin, CARLOS Ibanez, Wensu Yuan
exaly   +3 more sources

Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors

Biochemical and Biophysical Research Communications, 2005
Death receptors (DRs) can induce apoptosis by oligomerization with TRAIL, whereas death decoy receptors (DcRs) cannot, due to their lack of functional intracellular death domains. However, it is not known whether DRs and DcRs can interact with one another to form oligomeric complexes prior to TRAIL binding.
Hyun-Wook, Lee, Seung-Hyun, Lee, Hae-Won, Lee, Yeon-Woo, Ryu, Myung-Hee, Kwon, Yong-Sung, Kim   +5 more
openaire   +2 more sources

Apoptotic and necrotic cell death induced by death domain receptors

Cellular and Molecular Life Sciences, 2001
Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as initiators and effectors of apoptotic cell death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the ...
G, Denecker, D, Vercammen, W, Declercq, P, Vandenabeele   +3 more
openaire   +2 more sources

A death-domain-containing receptor that mediates apoptosis

Nature, 1996
The cell-killing effects of the cytokines TNF-alpha and FasL are mediated by the distinct cell-surface receptors TNFR1, TNFR2 and Fas (also known as CD95/APO-1), which are all members of a receptor superfamily that is important for regulating cell survival.
J, Kitson, T, Raven, Y P, Jiang, D V, Goeddel, K M, Giles, K T, Pun, C J, Grinham, R, Brown, S N, Farrow   +8 more
openaire   +2 more sources

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

Science, 1997
TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain–containing receptor, DR4, is expressed on both cell types. An antagonist decoy receptor (designated as TRID for TRAIL receptor without an intracellular domain) that may explain the resistant ...
G, Pan, J, Ni, Y F, Wei, G, Yu, R, Gentz, V M, Dixit   +5 more
openaire   +2 more sources

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

Nature, 2013
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) family of death receptors, including TNFR1 and TNFR2, and FAS and TNF-related apoptosis-inducing ligand (TRAIL) receptors.
Shan, Li, Li, Zhang, Qing, Yao, Lin, Li, Na, Dong, Jie, Rong, Wenqing, Gao, Xiaojun, Ding, Liming, Sun, Xing, Chen, She, Chen, Feng, Shao   +11 more
openaire   +2 more sources

Role of NMDA receptor functional domains in excitatory cell death

Neuropharmacology, 2000
The mechanisms by which the NMDA receptor (NMDAR) induces excitotoxicity were investigated using a novel assay. We quantitated the capacity of wild type and mutant receptors for cell killing in CHO cells and cultured cortical neurons by measuring the activity of a co-transfected firefly luciferase expression plasmid.
G A, Rameau, Y, Akaneya, L, Chiu, E B, Ziff   +3 more
openaire   +2 more sources

Equilibrium between monomers and dimers of the death domain of the p75 neurotrophin receptor in solution

International Journal of Biological Macromolecules, 2023
p75 neurotrophin receptor (p75NTR) contains a C-terminal globular protein module known as the death domain (DD), which plays a central role in apoptotic and inflammatory signaling through the formation of oligomeric protein complexes. A monomeric state of the p75NTR-DD also exists depending on its chemical environment in vitro.
Zhen, Li, Yajing, Duan, Wenhui, Mao, Cheng, Chen, Wensu, Yuan, Xinghua, Jin, Shuo, Shi, Xun-Cheng, Su, Carlos F, Ibáñez, Zhi, Lin   +9 more
openaire   +2 more sources

Solution structure of the tumor necrosis factor receptor-1 death domain

Journal of Molecular Biology, 2001
Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of ...
S F, Sukits, L L, Lin, S, Hsu, K, Malakian, R, Powers, G Y, Xu   +5 more
openaire   +2 more sources

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

Science, 1999
Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-κB) activation. Normally, these signals are generated only after TNF-induced receptor aggregation.
Y, Jiang, J D, Woronicz, W, Liu, D V, Goeddel   +3 more
openaire   +2 more sources